2019
DOI: 10.1007/s12325-019-01019-z
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A Comprehensive Update of Current Anesthesia Perspectives on Therapeutic Hypothermia

Abstract: Normal thermal regulation is a result of the integration of afferent sensory, central control, and efferent responses to temperature change. Therapeutic hypothermia (TH) is a technique utilized during surgery to protect vital organs from ischemia; however, in doing so leads to other physiological changes. Indications for inducing hypothermia have been described for neuroprotection, coronary artery bypass graft (CABG) surgery, surgical repair of thoracoabdominal and intracranial aneurysms, pulmonary thromboenda… Show more

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Cited by 11 publications
(14 citation statements)
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“…The IV anesthetics used during anesthesia, propofol and remifentanil, induced redistribution of blood volume by peripheral vasodilation, resulting in profound hypotension. 4 Profound hypotension was strongly associated with myocardial injury and especially harmful for this patient, who had preexisting ischemic heart disease. 17 Second, tachycardia, which may have been caused by the inotrope dopamine, used to compensate for the low BP or the stress response to surgical stimulation from shallow anesthetic depth, may have triggered myocardial ischemia by decreasing oxygen delivery and increasing oxygen consumption.…”
Section: Discussionmentioning
confidence: 81%
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“…The IV anesthetics used during anesthesia, propofol and remifentanil, induced redistribution of blood volume by peripheral vasodilation, resulting in profound hypotension. 4 Profound hypotension was strongly associated with myocardial injury and especially harmful for this patient, who had preexisting ischemic heart disease. 17 Second, tachycardia, which may have been caused by the inotrope dopamine, used to compensate for the low BP or the stress response to surgical stimulation from shallow anesthetic depth, may have triggered myocardial ischemia by decreasing oxygen delivery and increasing oxygen consumption.…”
Section: Discussionmentioning
confidence: 81%
“…Hypothermia affects the electrical conduction of myocardial cells, which can induce hypotension or bradycardia and even increase the risk of ventricular fibrillation by prolonging repolarization. 4,8 However, mild hypothermia of 32.0 C to 35.0 C demonstrates cardioprotective effects by decreasing myocardial oxygen demand and increasing myocardial perfusion through vasodilation of coronary vessels. 9 Therefore, there has been a growing interest in the clinical use of mild therapeutic hypothermia as an adjunctive therapy during ischemic heart disease.…”
Section: Discussionmentioning
confidence: 99%
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