A computational approach for the screening of potential antiviral compounds against SARS-CoV-2 protease: Ionic liquid vs herbal and natural compounds

Saraswat, Juhi; Singh, Prashant; Patel, Rajan

doi:10.1016/j.molliq.2021.115298

Cited by 43 publications

(31 citation statements)

References 47 publications

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“…Hence, a combination of this sort of synthesized formulation sets off as a superior preference owing to synergistic sequel and generates a consequential therapeutic effect. (49) A variety of Indian herbs have proven to be beneficial against infections and possess properties such as being antiviral, antibacterial and antifungal. (50)(51)(52) .…”

Section: Indian Herbs and Their Significance Against Sars-cov-2mentioning

confidence: 99%

Role of herbs for elevating immunity against SARS-CoV-2: a concise review

Anand,

Saraswat,

Patel

2021

Universa Medicina

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COVID-19 has emerged as a dreadful pandemic caused by the virus SARS-CoV-2. Though the number of patients recovering from infection is encouraging, sturdy cure is still being researched upon and the effective vaccines are yet to be rigidly resolute. COVID-19 has so far instigated a massive loss of lives globally and even the countries with the most advanced healthcare systems have come under its grasp. Health experts suggest in such case “Prevention is better than cure” which includes an appropriate daily lifestyle and a rugged immune system that could help mankind surmount this peril. This review highlights the importance of influential herbs and their medicinal significance. Biomedical articles were explored from PubMed, Google Scholar, Web of Science for the period of 2010-2021. Guidelines from the Ministry of Ayush (India) were also considered. The Ayurveda does not mention any cure for the novel coronavirus; however, it emphasizes the means of boosting one’s immunity. Accordingly, this article highlights some of the role of prevalent Ayurvedic herbs in promoting immunity for combating the novel coronavirus. The herbs in combination with drugs could be utilized for the sake of curtailing the side effects as well as the malefic repercussions of strong synthetic drugs used for treating COVID-19 patients, which would be a paramount leap in the field of Ayurveda as well as western-style medicine. However, the beneficial effects of these traditional medicines and their clinical trials remained to be known. We reviewed the latest updates on traditional medicines proposed for promoting immunity towards COVID-19.

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Section: Indian Herbs and Their Significance Against Sars-cov-2mentioning

confidence: 99%

Role of herbs for elevating immunity against SARS-CoV-2: a concise review

Anand,

Saraswat,

Patel

2021

Universa Medicina

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“…Gorla et al [64] have considered silymarin as a potent ACE-2-peptidase domain (PD)-ACE-2) inhibitor, due to the fact that silymarin maintains coupling with the active site. Saraswat et al [65] found that silymarin maintained binding with the principal protease of SARS-CoV-2; thus, it could be utilized as an antiviral agent. Another study demonstrated the binding of diverse phytochemicals, among these the silymarin of the viral protein, nonstructured protein 15 (Nsp15), which inhibited the replication of SARS-CoV-2 [66].…”

Section: Silymarin and Its Effect On Covid-19 And Diabetesmentioning

confidence: 99%

Phytochemicals and Their Possible Mechanisms in Managing COVID-19 and Diabetes

et al. 2021

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For the writing of this manuscript, we searched information published from 2000 to 2021, through PubMed, Web of Science, Springer, and Science Direct. Focusing on the effects related to respiratory diseases, in addition to possible direct effects towards SARS-CoV-2, coupled with diabetes. Diabetes is a metabolic disease that is characterized by affecting the function of glucose, in addition to insulin insufficiency. This leads to patients with such pathologies as being at greater risk for developing multiple complications and increase exposure to viruses infections. This is the case of severe acute respiratory disease coronavirus 19 (SARS-CoV-2), which gave rise to coronavirus disease 2019 (COVID-19), declared an international public health emergency in March of 2020 Currently, several strategies have been applied in order to prevent the majority of the consequences of COVID-19, especially in patients with chronic diseases such as diabetes. Among the possible treatment options, we found that the use of phytochemical compounds has exhibited beneficial effects for the prevention and inhibition of infection by SARS-CoV-2, as well as for the improvement of the manifestations of diabetes.

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“…SARS-CoV-2 has infected billions of people resulted about millions of deaths worldwide. Many people are found to be asymptomatic and recovered without medical intervention but those peoples are already suffering from any kind of illness, diabetes, asthma and respiratory disorders need medical treatments [ 4 , [6] , [7] , [8] , [9] ]. Remdesivir is a nucleotide prodrug that helps to inhibit viral- RNA dependent RNA-polymerases, that plays an important role in replication of viruses including coronaviridae.…”

Section: Introductionmentioning

confidence: 99%