PurposeThe purpose of this paper is to propose a new conceptual framework for big data analytics (BDA) in the healthcare sector for the European Mediterranean region. The objective of this new conceptual framework is to improve the health conditions in a dynamic region characterized by the appearance of new diseases.Design/methodology/approachThis study presents a new conceptual framework that could be employed in the European Mediterranean healthcare sector. Practically, this study can enhance medical services, taking smart decisions based on accurate data for healthcare and, finally, reducing the medical treatment costs, thanks to data quality control.FindingsThis research proposes a new conceptual framework for BDA in the healthcare sector that could be integrated in the European Mediterranean region. This framework introduces the big data quality (BDQ) module to filter and clean data that are provided from different European data sources. The BDQ module acts in a loop mode where bad data are redirected to their data source (e.g. European Centre for Disease Prevention and Control, university hospitals) to be corrected to improve the overall data quality in the proposed framework. Finally, clean data are directed to the BDA to take quick efficient decisions involving all the concerned stakeholders.Practical implicationsThis study proposes a new conceptual framework for executives in the healthcare sector to improve the decision-making process, decrease operational costs, enhance management performance and save human lives.Originality/valueThis study focused on big data management and BDQ in the European Mediterranean healthcare sector as a broadly considered fundamental condition for the quality of medical services and conditions.