A concise pathway to synthesize a novel class of pyrido(2,3-d)pyrimidine-C-β-d-glycosides

Shanmugam, Muniyappapillai Jeganathan; Das, Thangamuthu Mohan

doi:10.1016/j.carres.2012.11.013

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…In this title compound the C-S bond length is in computed to be 1.859Å while reported value is about 1.861Å [13]. The C-N bond length for the title compound is found to be 1.359Å which is in good agreement with literature [14]. Modafinil has a chiral centre at the sulphur atom.…”

Section: Geometrical Parameterssupporting

confidence: 81%

Molecular Conformational Analysis, Vibrational Spectra, NBO, HOMO–LUMO and Molecular docking of Modafinil Based on Density Functional Theory

Bharathy¹,

Prasana²,

Muthu³

2018

IJCRR

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Modafinil is a wakefulness-promoting agent used for treatment of disorders such as narcolepsy, Sleep disorders and excessive daytime sleepiness associated with obstructive sleep apnea. It has also been seen widespread psychostimulant used as a purported cognition-enhancing agent. IR and FT-Raman spectrum of Modafinil was analyzed. The vibrational wavenumber were computed using Density Functional Theory. The data obtained from wavenumber calculations are used to assign the vibrational bands obtained in the IR and Raman spectrum. The bond length and bond angles of the title compound are computed. NBO analysis, HOMO-LUMO, first and second order hyperpolarizability and molecular electrostatic potential results are also reported. PASS analysis of the Modafinil predicts sleep disorders treatment, activity with Pa (probability to be active) value of 0.822. Molecular docking studies exhibit the posing of ligand with the protein.

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Section: Geometrical Parameterssupporting

confidence: 81%

Molecular Conformational Analysis, Vibrational Spectra, NBO, HOMO–LUMO and Molecular docking of Modafinil Based on Density Functional Theory

Bharathy¹,

Prasana²,

Muthu³

2018

IJCRR

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“…Fluorescein-monoaldehyde 20-22 7 and 1-(4,6-O-butylidene-b-Dglucopyranosyl)propan-2-one (BGP) 23 14 were synthesized by adopting procedures reported in the literature. Fluorescein based b-aminoglycosylketones 15-20 were synthesized in onestep from the Mannich reaction of uorescein-monoaldehyde (7) with aromatic amines 8-13 and 1-(4,6-O-butylidene-b-D-glucopyranosyl)propan-2-one 14 in the presence of potassium carbonate (K 2 CO 3 ) as an inorganic catalyst (Scheme 1).…”

Section: Synthesis Of Uorescein Based B-aminoglycosylketonesmentioning

confidence: 99%

One-pot synthesis of fluorescein based β-aminoglycosylketones and their biological and material applications

Rajasekar

Das

2014

RSC Adv.

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Synthesis and antioxidant activity of a novel class of fluorescein-based β-C-glycosides

Rajasekar

Das

2013

Carbohydrate Research

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A concise pathway to synthesize a novel class of pyrido(2,3-d)pyrimidine-C-β-d-glycosides

Cited by 7 publications

References 28 publications

Molecular Conformational Analysis, Vibrational Spectra, NBO, HOMO–LUMO and Molecular docking of Modafinil Based on Density Functional Theory

Molecular Conformational Analysis, Vibrational Spectra, NBO, HOMO–LUMO and Molecular docking of Modafinil Based on Density Functional Theory

One-pot synthesis of fluorescein based β-aminoglycosylketones and their biological and material applications

Synthesis and antioxidant activity of a novel class of fluorescein-based β-C-glycosides

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