A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

Röschke, Joachim; Pk, Wagner

doi:10.1038/sj.npp.1300139

Cited by 59 publications

(51 citation statements)

References 17 publications

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“…Results of our study are in concordance with most studies in classic oddball tasks reporting N2b and P3b deficits (amplitude reduction and latency prolongation) in bipolar disorder (Gangadhar et al 1993;Muir et al 1991;O'Donnell et al 2004;Roschke and Wagner 2003;Salisbury et al 1999;Strik et al 1998). The bipolar patients have shown disturbances on the later stages when attentional and working memory mechanisms indexed by N2b and P3b are engaged (O'Donnell et al 2004).…”

Section: Discussionsupporting

confidence: 92%

“…The presence of a P3b reduction in manic-depressive patients is equivocal. Some studies have shown a reduction in amplitude (Gangadhar et al 1993;Roschke and Wagner 2003), but others have failed to find a reduced P3b amplitude (Hansenne et al 1994). P300 amplitude was reduced in bipolar psychotic disorder (Muir et al 1991), and in depressed patients (Bange and Bathien 1998;Salisbury et al 1998Salisbury et al , 1999Santosh et al 1994).…”

Section: Introductionmentioning

confidence: 99%

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Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Sokhadze

Tasman

Tamas

et al. 2010

Appl Psychophysiol Biofeedback

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There appears to be a significant disconnect between symptomatic and functional recovery in bipolar disorder (BD). Some evidence points to interepisode cognitive dysfunction. We tested the hypothesis that some of this dysfunction was related to emotional reactivity in euthymic bipolar subjects may effect cognitive processing. A modification of emotional gender categorization oddball task was used. The target was gender (probability 25%) of faces with negative, positive, and neutral emotional expression. The experiment had 720 trials (3 blocks × 240 trials each). Each stimulus was presented for 150 ms, and the EEG/ERP responses were recorded for 1,000 ms. The inter-trial interval was varied in 1,100-1,500 ms range to avoid expectancy effects. Task took about 35 min to complete. There were 9 BD and 9 control subjects matched for age and gender. Reaction time (RT) was globally slower in BD subjects. The centro-parietal amplitudes at N170 and N200, and P200 and P300 were generally smaller in the BD group compared to controls. Latency was shorter to neutral and negative targets in BD. Frontal P200 amplitude was higher to emotional negative facial non-targets in BD subjects. The frontal N200 in response to positive facial emotion was less negative in BD subjects. The frontal P300 of BD subjects was lower to emotionally neutral targets. ERP responses to facial emotion in BD subjects varied significantly from normal controls. These variations are consistent with the common depressive symptomology seen in long term studies of bipolar subjects.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Sokhadze

Tasman

Tamas

et al. 2010

Appl Psychophysiol Biofeedback

View full text Add to dashboard Cite

show abstract

“…For instance, it has been reported that major depression is related to P300 amplitude reduction (Anderer et al, 2002;Blackwood et al, 1987;Gangadhar et al, 1993;Roschke and Wagner, 2003) and one could argue that this could have contributed to the amplitude reduction observed in participants with OCD compared to the GTS and control groups. However, covariance analysis revealed that group differences remained statistically significant after depressive symptoms had been introduced as a covariable.…”

Section: Possible Influences Of Confounding Variablesmentioning

confidence: 99%

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Approximately 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms (OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS+OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region. These findings suggest that adults with GTS are characterized by enhanced working memory updating processes and that the superimposition of OCS can lead to a reduction of these processes. The discrepancy between our findings and results obtained in previous studies on GTS could reflect the modulating effect of OCS on late ERP components.

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“…The P300 ERP is thought to reflect the degree to which attention is allocated and incoming information is processed and incorporated into working memory [Donchin et al, 1986;Polich and Herbst, 2000]. Numerous studies have shown that low amplitude P300 is associated with psychopathology including MD [Bruder et al, 1995;Roschke and Wagner, 2003], alcoholism [Begleiter et al, 1984;Hill and Steinhauer, 1993;Reese and Polich, 2003], impulsivity and antisocial personality disorder [Iacono et al, 2002;Justus et al, 2001], and schizophrenia [Higashima et al, 2003;Jeon and Polich, 2003]. Only a few studies have looked at the relationship between anxiety and P300.…”

Section: Introductionmentioning

confidence: 99%

Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders

et al. 2008

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Anxiety disorders are often comorbid with major depression (MD) and alcohol use disorders (AUD). Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. We hypothesized that attentional response and working memory (auditory P300 event-related potential and Weschler Adult Intelligence Scale, Revised digit symbol scores) as well as genetic vulnerability would differ between pure anxiety disorders and comorbid anxiety. Our study sample comprised 249 community-ascertained men and women with lifetime DSM-III-R diagnoses. We analyzed groups of participants with pure anxiety disorders, pure MD, pure AUD, comorbid anxiety, and no psychiatric disorder. Participants were well at the time of testing; state anxiety and depressed mood measures were at most only mildly elevated. Individuals with pure anxiety disorders had elevated P300 amplitudes (P=0.0004) and higher digit symbol scores (P<0.0001) compared with all the other groups. Individuals with comorbid anxiety had the greatest proportion of COMT Met158 and BDNF Met66 alleles (P=0.009) as well as higher harm avoidance-neuroticism (P<0.0005) than all other groups. Our results suggest that there may be two vulnerability factors for anxiety disorders with differing genetic susceptibility: (a) heightened attention and better working memory with mildly elevated anxiety-neuroticism, a constellation that may be protective against other psychopathology; and (b) poorer attention and working memory with greater anxiety-neuroticism, a constellation that may also increase vulnerability to AUD and MD. This refinement of the anxiety phenotype may have implications for therapeutic interventions.

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A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

Cited by 59 publications

References 17 publications

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders

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