A conjugated-polymer-based ratiometric nanoprobe for evaluating in-vivo hepatotoxicity induced by herbal medicine via MSOT imaging

Wu, Yinglong; Sun, Linhui; Zeng, Fang; Wu, Shuizhu

doi:10.1016/j.pacs.2018.11.002

Cited by 29 publications

(10 citation statements)

References 66 publications

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“…This small molecule approach for PA probe optimization is in contrast to recent nanoparticle-based examples which focus on for enhancing the sensitivity of NOresponsive PA by co-administering inert or analyte-selective probes for internal calibration or added sensitivity. 38,39 More broadly, this work provides a new approach for the optimization of activatable PA probes and bridging the gap in sensitivity between optical and photoacoustic imaging methods.…”

Section: Resultsmentioning

confidence: 99%

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Reinhardt

Chan

2020

Chem. Sci.

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Nitric oxide (NO) is a key signaling molecule involved in a variety of physiological and pathological processes. Over the past few decades it has become clear that the microenvironment and concentration of NO are critically linked to its bioactivity. Direct visualization of NO in vivo remains difficult due to a lack of sensitive analytical tools with deep tissue compatibility. Herein, we report the optimization of an activatable photoacoustic probe for NO by planarizing the boron-azadipyrromethene (aza-BODIPY) dye platform via steric relaxation. The lead compound, SR-APNO-3, exhibits maximal absorption at 790 and 704 nm before and after N-nitrosation with NO, respectively, and a 4.4-fold increase in the theoretical maximal ratiometric response compared to the non-sterically relaxed parent compound, APNO-5. This circa 30 nm red-shift enabled direct visualization with the laser system commonly employed in commercially available photoacoustic tomographers and a 1.1-fold increase in sensitivity within an intramuscular lipopolysaccharide-induced inflammation model. Moreover, this optimization facilitated the detection of endogenously produced NO in an allograft murine breast cancer model, where steadystate concentrations are several orders of magnitude less than during the immune response.

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Section: Resultsmentioning

confidence: 99%

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Reinhardt

Chan

2020

Chem. Sci.

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“…Liver function assessed by indocyanine green (ICG) clearance and subsequently imaged with optoacoustics was used as a measure for acute acetaminophen-induced hepatotoxicity [ 75 ]. Additionally, herbal medicine-induced damage could be graded by a liposomal nanoprobe consisting of a NO responsive dye and a diketopyrrolopyrrole-based conjugated polymer [ 76 ]. Similar probes, either for detection of H 2 S or leucine aminopeptidase, were reported to be detectable by OAI after undergoing absorption redshifting [ 77 , 78 ].…”

Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

Optoacoustic Imaging in Inflammation

et al. 2021

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Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of “light in” and “sound out” offers unprecedented scalability with a high penetration depth and resolution. The wide range of biomedical applications makes this technology a versatile tool for preclinical and clinical research. Particularly when imaging inflammation, the technology offers advantages over current clinical methods to diagnose, stage, and monitor physiological and pathophysiological processes. This review discusses the clinical perspective of using OAI in the context of imaging inflammation as well as in current and emerging translational applications.

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“…Эти соединения могут вызвать развитие внутрипеченочного оксидативного/нитрозативного стресса, который способствует инициации и прогрессированию повреждения печени. Установлено, что визуализация с помощью мультиспектральной оптико-акустической томографической системы позволяет обнаружить повышение уровня NO в печени и точно определить локализацию повреждения [44].…”

Section: гепатотоксическое действие лекарственных растительных препаратовunclassified

Safety of Herbal Medicines: Clinical and Pharmacological Aspects

Демидова¹,

Архипов²,

Журавлева³

et al. 2020

Bezopasnost' i risk farmakoterapii

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Herbal medicines make up a large part of all medicinal products in the Russian market. Complex combinations of biologically active substances that are used as components in herbal medicines not only determine their therapeutic efficacy, but can also cause adverse reactions. The aim of this review was to analyse data on adverse effects of herbal medicines, and reasons and mechanisms behind their development. Special attention should be given to hepatotoxic and nephrotoxic effects of biologically active substances that are used as components in herbal medicines, because liver and kidney failure may lead to life-threatening conditions. The paper addresses hepatic adverse effects, including sinusoidal obstruction syndrome, caused by toxic biologically active substances of the pyrrolizidine alkaloids group. The paper summarises data on herbal medicines and toxic biologically active substances causing acute kidney injury and chronic kidney disease. It analyses potential clinically significant interactions that may occur during co-use of herbal and other types of medicines due to their pharmacokinetic and pharmacodynamic interactions. Further research involving collection, systematisation, and analysis of adverse effects of herbal medicines used alone or in combination with other medicinal products is needed to improve the safety of pharmacotherapy.

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A conjugated-polymer-based ratiometric nanoprobe for evaluating in-vivo hepatotoxicity induced by herbal medicine via MSOT imaging

Abstract: Graphical abstract

Cited by 29 publications

References 66 publications

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Optoacoustic Imaging in Inflammation

Safety of Herbal Medicines: Clinical and Pharmacological Aspects

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