2024
DOI: 10.1101/2024.07.18.604039
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A conjugative plasmid exploits flagella rotation as a cue to facilitate its transfer

Saurabh Bhattacharya,
Michal Bejerano-Sagie,
Miriam Ravins
et al.

Abstract: Conjugation-mediated DNA delivery is the primary mode for antibiotic resistance spread; yet, molecular mechanisms regulating the process remain largely unexplored. While conjugative plasmids typically rely on solid surfaces to facilitate donor-to-recipient proximity, the pLS20 conjugative plasmid, prevalent among Gram-positiveBacillusspp., uniquely requires fluid environments to motivate its transfer. Here we unveiled that pLS20, carried byB. subtilis, induces adhesin-promoted multicellular clustering, which c… Show more

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