A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Waning, David L.; Guise, Theresa A.; Mohammad, Khalid S.

doi:10.1016/j.cmet.2018.12.014

Cited by 15 publications

(7 citation statements)

References 9 publications

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“…During this process, the release of growth factors, such as transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), insulin-like growth factors (IGFs), BMPs, and calcium, is ongoing in the bone microenvironment. It was proven that the increase in intracellular calcium levels among BC cells could interfere with the osteogenic function and facilitate survival [43]. TGF-β is a pleiotropically expressed multifunctional cytokine that controls tissue homeostasis by regulating cellular apoptosis, proliferation, and differentiation [45].…”

Section: Survivalmentioning

confidence: 99%

Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems

Shao

Varamini

2022

Cells

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Bone is one of the most common metastatic sites among breast cancer (BC) patients. Once bone metastasis is developed, patients’ survival and quality of life will be significantly declined. At present, there are limited therapeutic options for BC patients with bone metastasis. Different nanotechnology-based delivery systems have been developed aiming to specifically deliver the therapeutic agents to the bone. The conjugation of targeting agents to nanoparticles can enhance the selective delivery of various payloads to the metastatic bone lesion. The current review highlights promising and emerging advanced nanotechnologies designed for targeted delivery of anticancer therapeutics, contrast agents, photodynamic and photothermal materials to the bone to achieve the goal of treatment, diagnosis, and prevention of BC bone metastasis. A better understanding of various properties of these new therapeutic approaches may open up new landscapes in medicine towards improving the quality of life and overall survival of BC patients who experience bone metastasis.

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Section: Survivalmentioning

confidence: 99%

Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems

Shao

Varamini

2022

Cells

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“…In particular, the abundant calcium in the bone matrix can attract the calcium-sensing receptor-expressing breast cancer cells to the bone. Furthermore, Wang et al (2018) showed that the increased intracellular calcium concentration in metastatic breast cancer cells induced by connexin 43 can disturb the osteogenic niche and promote survival (Waning et al, 2019). Furthermore, the bone microenvironment promotes breast cancer cells to transit to a migratory phenotype with new malignant capacities.…”

Section: Adhesion and Survivalmentioning

confidence: 99%

RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies

Dang

et al. 2020

Front. Cell Dev. Biol.

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Breast cancer remains one of the most life-threatening tumors affecting women. Most patients with advanced breast cancer eventually develop metastatic diseases, which cause significant morbidity and mortality. Approximately two-thirds of patients with advanced breast cancer exhibit osteolytic-type bone metastasis, which seriously reduce the quality of life. Therefore, development of novel therapeutic strategies for treating breast cancer patients with bone metastasis is urgently required. The "seed and soil" theory, which describes the interaction between the circulating breast cancer cells (seeds) and bone microenvironment (soil), is widely accepted as the mechanism underlying metastasis. Disruption of any step in this cycle might have promising antimetastasis implications. The interaction of receptor activator of nuclear factor-κB ligand (RANKL) and its receptor RANK is fundamental in this vicious cycle and has been shown to be a novel effective therapeutic target. A series of therapeutic strategies have been developed to intervene in this cross-talk. Therefore, in this review, we have systematically introduced the functions of the RANKL/RANK signaling system in breast cancer and discussed related therapeutic strategies.

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“…Many clinical diseases can lead to bone defects and reduced bone formation, including fractures (Matsumoto et al, 2010), bone tumors (Waning et al, 2019), osteoporosis (Cao et al, 2012), and so on. The commonly used treatments, such as bone transplantation, are still very limited.…”

Section: Application Of Msc-derived Exosomes In Bone Tissue Engineeringmentioning

confidence: 99%

The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases

Lyu

Xiao

Guo

et al. 2020

Front. Cell Dev. Biol.

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Bone-derived exosomes are naturally existing nano-sized extracellular vesicles secreted by various cells, such as bone marrow stromal cells, osteoclasts, osteoblasts, and osteocytes, containing multifarious proteins, lipids, and nucleic acids. Accumulating evidence indicates that bone-derived exosomes are involved in the regulation of skeletal metabolism and extraosseous diseases through modulating intercellular communication and the transfer of materials. Following the development of research, we found that exosomes can be considered as a potential candidate as a drug delivery carrier thanks to its ability to transport molecules into targeted cells with high stability, safety, and efficiency. This review aims to discuss the emerging role of bone-derived exosomes in skeletal metabolism and extraosseous diseases as well as their potential role as candidate biomarkers or for developing new therapeutic strategies.

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A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Cited by 15 publications

References 9 publications

Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems

Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems

RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies

The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases

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