Abstract:of other eIF4F subunits and ATP to the rate of formation and stability of the eIF4E-cap complex, characterizing the kinetics of cap recognition. Our results suggest that mRNAs are inherently recognized at different rates by eIF4F, which can contribute to the wide range of translational efficiencies observed in vivo. Specifically, our findings highlight how factor composition and variations in mRNA features could tune the dynamics of protein synthesis by altering the rates of events during early initiation. Our… Show more
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