A contemporary insight into SARS-CoV-2 pathophysiology, retrieved threat of mutants and prospect of vaccine development

Dash, Rasmita; Mohapatra, Sujata

doi:10.23736/s2724-542x.21.02765-8

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…Downregulating the intracellular transcription factors such as NF-kB, cyclooxygenase II, matrix metalloproteinase-9, activator protein 1, STAT3, and nitric oxide synthase has been remarkably induced apoptosis in different cell lines with curcumin treatment. [ 27 28 29 ] By inhibiting pyruvate kinase M2 (PKM2), curcumin has been found to offer a novel anticancer mechanism that lowers glucose absorption and lactate generation (the Warburg effect) in cancer cells. The PKM2 downregulation was accomplished by subduing the mammalian targets of rapamycin–hypoxia-inducible factor 1α.…”

Section: Role Of Natural Compounds In the Emerging Era Of Repurposingmentioning

confidence: 99%

“…Drug repurposing, also known as (drug reprofiling, redirecting, repositioning and drug rediscovery) states the investigation of existing drugs for new therapeutic purposes. [ 3 ] At a high attrition rate, considerable prices and steady steps of novel drug discovery and development and repurposing of preexisting drugs to deal with cancers have progressively become an eye-catching proposition. The intensifying budget and the requisite time period for novel drug development cost millions of dollars, and for every dollar expended on research and development, it has been assessed that below a dollar of worth is refunded on average.…”

Section: Introductionmentioning

confidence: 99%

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Drug repurposing a compelling cancer strategy with bottomless opportunities

Dash,

Yadav,

Biswal

et al. 2023

Indian Journal of Pharmacology

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Drug discovery has customarily focused on a de novo design approach, which is extremely expensive and takes several years to evolve before reaching the market. Discovering novel therapeutic benefits for the current drugs could contribute to new treatment alternatives for individuals with complex medical demands that are safe, inexpensive, and timely. In this consequence, when pharmaceutically yield and oncology drug efficacy appear to have hit a stalemate, drug repurposing is a fascinating method for improving cancer treatment. This review gathered about how in silico drug repurposing offers the opportunity to quickly increase the anticancer drug arsenal and, more importantly, overcome some of the limits of existing cancer therapies against both old and new therapeutic targets in oncology. The ancient nononcology compounds' innovative potential targets and important signaling pathways in cancer therapy are also discussed. This review also includes many plant-derived chemical compounds that have shown potential anticancer properties in recent years. Here, we have also tried to bring the spotlight on the new mechanisms to support clinical research, which may become increasingly essential in the future; at the same time, the unsolved or failed clinical trial study should be reinvestigated further based on the techniques and information provided. These encouraging findings, combined together, will through new insight on repurposing more non-oncology drugs for the treatment of cancer.

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Section: Role Of Natural Compounds In the Emerging Era Of Repurposingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drug repurposing a compelling cancer strategy with bottomless opportunities

Dash,

Yadav,

Biswal

et al. 2023

Indian Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…The intricate mRNAs molecules have difficulty in entering the cells on their own as they rapidly degrade in body fluids. Lipid nanoparticle technology for effective delivery of mRNA into cells and into the cytoplasm, where it can be translated by ribosomes into the necessary protein, has been a major advance 17 , 18 . COVID-19 vaccines are consequently heavily dependent on the complementary use of drug delivery and nanotechnology.…”

mentioning

confidence: 99%