A Continuous Add‐On Probe Reveals the Nonlinear Enlargement of Mitochondria in Light‐Activated Oncosis

Wang, Kang‐Nan; Shao, Xintian; Tian, Ze; Liu, Liu‐Yi; Zhang, Chengying; Tan, Cai‐Ping; Zhang, Jie; Ling, Peixue; Liu, Fei; Chen, Qixin; Diao, Jiajie; Mao, Zong‐Wan

doi:10.1002/advs.202004566

Cited by 26 publications

(18 citation statements)

References 52 publications

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“…The apoptosis of macrophages is related to organelles such as mitochondria ( Chen et al, 2020 ; Wang K. et al, 2020 ; Chen et al, 2021 ; Liu et al, 2021a ; Liu et al, 2021b ) ( Figure 1 ). Mitochondria are not only the main sites for intracellular oxidative phosphorylation and the formation of ATP ( Wei et al, 2022 ), but also the sites for the production of ROS ( Forte et al, 2021 ; Wang et al, 2021 ). Oxidation and endoplasmic reticulum (ER) stress can accelerate the apoptosis of macrophages ( Cominacini et al, 2015 ).…”

Section: Opioids Affect the Apoptosis Of Macrophagesmentioning

confidence: 99%

Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles

et al. 2022

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Opioids are the most widely used analgesics and therefore have often been the focus of pharmacological research. Macrophages are the most plastic cells in the hematopoietic system. They show great functional diversity in various organism tissues and are an important consideration for the study of phagocytosis, cellular immunity, and molecular immunology. The expression of opioid receptors in macrophages indicates that opioid drugs act on macrophages and regulate their functions. This article reviewed the collection of research on effects of opioids on macrophage function. Studies show that opioids, both endogenous and exogenous, can affect the function of macrophages, effecting their proliferation, chemotaxis, transport, phagocytosis, expression of cytokines and chemokine receptors, synthesis and secretion of cytokines, polarization, and apoptosis. Many of these effects are closely associated with mitochondrial function and functions of other organelles in macrophages. Therefore, in depth research into effects of opioids on macrophage organelles may lead to some interesting new discoveries. In view of the important role of macrophages in HIV infection and tumor progression, this review also discusses effects of opioids on macrophages in these two pathological conditions.

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Section: Opioids Affect the Apoptosis Of Macrophagesmentioning

confidence: 99%

Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles

et al. 2022

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“…The Annexin V-FITC apoptosis detection kit was adopted to analyze cell apoptosis (Wang et al., 2021 ). In short, a six-well plate (5 × 10 4 cells/well) was used to culture 4T1 cells.…”

Section: Methodsmentioning

confidence: 99%

Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity

Wang

Yin

et al. 2022

Drug Delivery

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Breast cancer is prevalent and diverse with significantly high incidence and mortality rates. Curcumin (Cur), a polyphenol component of turmeric, has been widely recognized as having strong anti-breast cancer activity. However, its anti-cancer efficiency is largely impaired by some of its concomitant negative properties, including its poor solubility, low cellular uptake, and severe reported side effects. Hence, the necessity arises to develop a novel low-toxic and high-efficiency targeting drug delivery system (DDS). In this study, we developed a pH-sensitive tumor self-targeting DDS (Cur@HFn) based on self-assembled HFn loaded with Cur, in which Cur was encapsulated into HFn cavity by using a disassembly/reassembly strategy, and the Cur@HFn was characterized by ultraviolet–visible (UV–vis), dynamic light scattering (DLS), and transmission electron microscope (TEM). A variety of breast cancer cell models were built to evaluate cytotoxicity, apoptosis, targeting properties, and uptake mechanism of the Cur@HFn. The pharmacodynamics was also evaluated in tumor (4T1) bearing mice after intravenous injection. In vitro release experiments showed that Cur@HFn is pH sensitive and shows sustained drug release under slightly acidic conditions. Compared with Cur, Cur@HFn has stronger cytotoxicity, cellular uptake, and targeting performance. Our study supported that Cur@HFn has a higher in vivo therapeutic effect and lower systemic toxicity. The safety evaluation results indicated that Cur@HFn has no hematotoxicity, hepatotoxicity, and nephrotoxicity. The findings of the present study showed that the Cur@HFn has been successfully prepared and has potential application value in the treatment of breast cancer.

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“…Manifested as DNA damage and mitochondrial swelling, oncosis is a type of programmed cell death different from apoptosis in both morphological changes and internal pathways. 6 The swelling of oncosis cells is mainly due to the failure of the ion pump on the membrane, which leads to water and sodium retention in the cells. 7 Related literature reported that oncosis might be involved in the process of tumor progression, including cancer metabolism, immunosuppression, and cancer stem cells.…”

Section: Introductionmentioning

confidence: 99%

Construction of an algorithm based on oncosis‐related LncRNAs comprising the molecular subtypes and a risk assessment model in lung adenocarcinoma

Chen

Zhou

et al. 2022

Clinical Laboratory Analysis

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Background As an important non‐apoptotic cell death method, oncosis has been reported to be closely associated with tumors in recent years. However, few research reported the relationship between oncosis and lung cancer. Methods In this study, we established an oncosis‐based algorithm comprised of cluster grouping and a risk assessment model to predict the survival outcomes and related tumor immunity of patients with lung adenocarcinomas (LUAD). We selected 11 oncosis‐related lncRNAs associated with the prognosis (CARD8‐AS1, LINC00941, LINC01137, LINC01116, AC010980.2, LINC00324, AL365203.2, AL606489.1, AC004687.1, HLA‐DQB1‐AS1, and AL590226.1) to divide the LUAD patients into different clusters and different risk groups. Compared with patients in clsuter1, patients in cluster2 had a survival advantage and had a relatively more active tumor immunity. Subsequently, we constructed a risk assessment model to distinguish between patients into different risk groups, in which low‐risk patients tend to have a better prognosis. GO enrichment analysis revealed that the risk assessment model was closely related to immune activities. In addition, low‐risk patients tended to have a higher content of immune cells and stromal cells in tumor microenvironment, higher expression of PD‐1, CTLA‐4, HAVCR2, and were more sensitive to immune checkpoint inhibitors (ICIs), including PD‐1/CTLA‐4 inhibitors. The risk score had a significantly positive correlation with tumor mutation burden (TMB). The survival curve of the novel oncosis‐based algorithm suggested that low‐risk patients in cluster2 have the most obvious survival advantage. Conclusion The novel oncosis‐based algorithm investigated the prognosis and the related tumor immunity of patients with LUAD, which could provide theoretical support for customized individual treatment for LUAD patients.

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A Continuous Add‐On Probe Reveals the Nonlinear Enlargement of Mitochondria in Light‐Activated Oncosis

Cited by 26 publications

References 52 publications

Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles

Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles

Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity

Construction of an algorithm based on oncosis‐related LncRNAs comprising the molecular subtypes and a risk assessment model in lung adenocarcinoma

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