A Contribution to an Understanding of Complexing Agents and Salt Solutions Reaction Mechanism on Chemical Attack of Type I Molded Glass Containers

Biavati, Alberto; Severi, Giorgia; Bisceglie, Franco; Marchegiani, Milena; Ferrarini, Arianna

doi:10.5731/pdajpst.2018.009506

Cited by 2 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 Similarly to alkaline attack, the presence of buffers with strong ionic strength (KCl and citric acid for instance) or complexing agents such as EDTA, glutaric acid, and phosphate are known to promote an extensive interaction with the glass network to cause its total dissolution. 18 Recent studies 19 have investigated the effect of dicarboxylic acids (aspartic and glutamic acids) homologue to glycine on glass vials corrosion. It was found that at pH 9, the silica dissolution in glycine is lower than in water.…”

Section: Chemical Behaviormentioning

confidence: 99%

“…Recent studies 19 have investigated the effect of dicarboxylic acids (aspartic and glutamic acids) homologue to glycine on glass vials corrosion. It was found that at pH 9, the silica dissolution in glycine is lower than in water.…”

Section: Borosilicate Glassesmentioning

confidence: 99%

“…Interaction of Type I molded vials with complexing agents in the pH range 5.8–10 homologous series from glycine: dicarboxylic acids with a –NH2 group in position 2 with alkyl chain of 4 and 5 C‐ atoms. From 19 …”

Section: Borosilicate Glassesmentioning

confidence: 99%

See 2 more Smart Citations

Glass: The best material for pharmaceutical packaging

Guadagnino¹,

Guglielmi

Nicoletti³

2022

Int J of Appl Glass Sci

View full text Add to dashboard Cite

Glass is the most used material in pharmaceutical packaging, and the production volumes are continuously growing. The reasons why glass can be considered the best material for pharmaceutical containers are discussed. A current picture of this area, which was showcased during the Covid-19 pandemic, is provided. Borosilicate glass products, which are currently the most used among those described by the Pharmacopoeia, are mostly considered, but new glasses that may be introduced in the future are also mentioned. A short view on the evolution of this type of glass and the current market situation are provided. Particular emphasis is given to chemical durability. Glasses are generally considered inert from the chemical point of view, but this is not exactly true. Phenomena such as the release of elemental impurities into solution, buffer interaction, and delamination have caused much concern in the last decade or so, especially as the complexity and value of drugs has been increasing. These phenomena are described, and it is pointed out that, thanks to the increasing scientific knowledge and production technologies, these issues are now under control, and the products on the market are of very high quality and very reliable.

show abstract

Section: Chemical Behaviormentioning

confidence: 99%

Section: Borosilicate Glassesmentioning

confidence: 99%