A Controlled Family History Study of Prepubertal Major Depressive Disorder

Puig-Antich, Joaquim; Goetz, Deborah; Davies, Mark; Kaplan, Thelma; Davies, Sharon; Ostrow, Lynn; Asnis, L; Twomey, J. F.; Iyengar, Satish; Ryan, Neal D.

doi:10.1001/archpsyc.1989.01810050020005

Cited by 269 publications

(112 citation statements)

References 170 publications

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“…Offspring of parents with a MDD are at increased risk for developing a depressive disorder (Weissman et al, 1987;Orvaschel et al, 1988;Puig-Antich et al, 1989). Four findings of the present study support the conclusion that difficult temperament, as measured by the DOTS (Lerner et al, 1982), partially mediates the relation between parental depression and childhood depression.…”

Section: Discussionsupporting

confidence: 80%

“…Numerous longitudinal and family history studies have demonstrated that the offspring of parents with Major Depressive Disorder (MDD) are at a two-to three-fold increased risk for developing depression as compared to the offspring of parents without a history of this disorder (Weissman et al, 1987;Orvaschel et al, 1988;Puig-Antich et al, 1989). The depression faced by these offspring is impairing; yet few receive any treatment (Weissman et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Temperament among offspring at high and low risk for depression

Bruder-Costello

Warner

Talati

et al. 2007

Psychiatry Research

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The purpose of this study was to examine relationships between parental depression, offspring temperament, and offspring major depressive disorder (MDD), and to determine whether difficult temperament, as measured by the Dimensions of Temperament Survey (DOTS), mediates the relation between parental MDD and offspring MDD. Offspring (n=169) of depressed or never depressed parents were followed over approximately 20 years and were blindly assessed up to 4 times (Waves 1 to 4) using semi-structured interviews. Offspring completed the DOTS at the time of first or second assessment. The results showed: (1) high-risk offspring with one or more depressed parent were significantly more likely than offspring with neither parent depressed parent to have a difficult temperament; (2) offspring with a difficult temperament were more than twice as likely as those with an easy temperament to develop a MDD; and (3) difficult temperament explained more than 10% of the association between parental depression and new onsets of MDD in offspring. The findings suggest that offspring temperament is associated with development of MDD and that difficult temperament at least partially mediates the relationship between parental depression and offspring depression. When identifying those at greatest risk for MDD, measures of temperament could serve as a useful supplement to family psychiatric history of MDD. Keywords Dimensions of Temperament Survey (DOTS); Major depressive disorder (MDD)

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Temperament among offspring at high and low risk for depression

Bruder-Costello

Warner

Talati

et al. 2007

Psychiatry Research

View full text Add to dashboard Cite

show abstract

“…Scientists believe that the interplay of several factors which lead to depression is very complex. Family studies have shown that 20 to 50 percent of children and adolescents who experience depression have a positive family history of depression 15,16,17,18 and children of depressed parents are three times more likely to experience a depressive disorder 19 . They are also more vulnerable to other mental and somatic disorders 20 .…”

Section: Risk Factorsmentioning

confidence: 99%

Suicidal Cut Throat Injuries: Management Modalities

Adoga¹

2012

Mental Illnesses - Understanding, Prediction and Control

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“…Excepto para tres franjas de edad: infancia, adolescencia y ancianidad. Hoy ya sabemos que, en las dos primeras, deben evitarse, como ya veníamos manteniendo hace años (19,40,41). En la última, en la ancianidad, que deben monitorizarse con sumo cuidado.…”

Section: En Las Suaves Colinas Escocesas: La Mina Y La Familia Real Bunclassified

Salud mental, ciudades y urbanismo: 1. Sobre psicosomática y psicodinámica de la vida urbana

Tizón

2006

Rev. Asoc. Esp. Neuropsiq.

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A Controlled Family History Study of Prepubertal Major Depressive Disorder

Cited by 269 publications

References 170 publications

Temperament among offspring at high and low risk for depression

Temperament among offspring at high and low risk for depression

Suicidal Cut Throat Injuries: Management Modalities

Salud mental, ciudades y urbanismo: 1. Sobre psicosomática y psicodinámica de la vida urbana

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