A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions of <i>Terminalia avicennioides</i> in laboratory animal models

Сулейман, М. М.; Oyelowo, B. B.; Ahmed, Amran; Mamman, M.; Bello, Kamar-deen T.

doi:10.1016/j.ijvsm.2017.04.002

Cited by 40 publications

(18 citation statements)

References 26 publications

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“…The CABAE administration significantly protected against all castor oil–induced deregulation of oxidative stress parameters in a dose‐dependent manner and returned their levels to near normal with the highest dose. In the same context, the implication of oxidative stress in the castor oil–induced intestinal hypersecretion was previously reported in many studies leading to an excessive ROS production such as O 2 •− , ROO • , HOCl, and OH• 2‐70 …”

Section: Discussionsupporting

confidence: 60%

“…Antidiarrheal properties and GIT inhibition were previously reported for many medicinal plant extracts, such as Matricaria recutita , 2 Myrtus communis , 10 Ceratonia siliqua , 69 and Salvia officinalis 34 . Clonidine and yohimbine, used as reference molecules, respectively, inhibited and stimulated the GIT 10‐69 …”

Section: Discussionmentioning

confidence: 83%

“…63 Furthermore, flavonoids like apegenin have a negative effect on the acetylcholine liberation leading to intestinal propulsion decrease. 64 Other studies reported that polyhenols are primal for prostaglandin synthesis depletion by inhibiting intestinal motility electrolytes secretion leading to intestinal mucosa alteration, 65 which gives plants a broad spectrum for the treatment of diarrheal diseases. 66 The Loperamide (10 mg/kg b.w.,p.o.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Sammari

Jedidi

Selmi

et al. 2020

Neurogastroenterology Motil

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Background: Diarrhea is a multifactorial gastrointestinal disorder responsible for about 5 million deaths annually. The chemical composition, the antioxidant activity of Crataegus azarolus berries aqueous extract (CABAE) as well as its protective effects against castor oil-induced diarrhea, oxidative stress, and inflammation in rat were studied.Methods: Sixty male rats were used and divided into six groups of ten animals in each: Control (C), castor oil (CO), CO+various doses of CABAE (100, 200, and 400 mg/kg b.w., p.o.), and CO+loperamide (LOP, 10 mg/kg b.w., p.o.).

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Sammari

Jedidi

Selmi

et al. 2020

Neurogastroenterology Motil

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“…Atropine is a competitive antagonist of acetylcholine muscarinic receptor [28] located on the intestinal smooth muscle. The activation of these receptors induces the production of the second messengers IP 3 and Diacyl glycerol (DAG) which are responsible for the increase of cytosolic calcium and smooth muscle contraction [11, 29, 30]. Like in the ethanolic extract of Bixa Orellana [14], phytochemical studies of the hydroethanolic extract revealed the presence of flavonoids, triterpenes, and tannins.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice

Tagne

Akaou

Noubissi

et al. 2019

Gastroenterology Research and Practice

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Objective The treatment of diarrheal diseases is a serious problem in developing countries, where population generally uses medicinal plants. The leaves of Bixa orellana have been reported to be traditionally used in the treatment of diarrhea by local people in the district of Khulna in Bangladesh. The aim of this study was to investigate the effects of the hydroethanolic extract of Bixa orellana leaves on castor oil-induced diarrhea in mice. Methods The powder of the leaves of Bixa orellana was macerated in ethanol/water mixture (20/80) for 48 hours and then filtered. The filtrate obtained was lyophilized, and the solutions to be administered to the animals were prepared. To induce diarrhea, animals orally received castor oil (1 mL/100 g bw). To determine the effective doses, each mouse received, 30 minutes after the administration of castor oil, one of the single oral doses of hydroethanolic extract of Bixa orellana leaves: 0, 25, 50, 100, and 200 mg/kg bw. The mass, number, and frequency of stool diarrhea were measured and recorded per hour for five hours. The effect of the hydroethanolic extract of Bixa orellana leaves on the intestinal transit was evaluated by measuring the distance traveled by the charcoal meal in thirty minutes. The effects of the aqueous extract of hydroethanolic extract of Bixa orellana leaves on intestinal secretion were evaluated by measuring the volume of the intestinal content and by dosing the electrolytes (Na+, K+, and Cl−) in the intestinal content by the colorimetric method. Results The extract produced significant (P < 0.01) decreases, respectively, 35.52%, 54.47%, 74.80%, and 87.80% in the severity of diarrhea. The extract at 100 and 200 mg/kg bw showed a significant (P < 0.01) decrease of castor oil-induced enteropooling (61.08% and 65.41%), and only the 200 mg/kg bw exhibited significant (P < 0.01) reduction on intestinal transit (24.46%) as compared to standard drug. Conclusions The hydroethanolic extract was found to be effective against castor oil-induced diarrhea in experimental mice at 50, 100, and 200 mg/kg bw which provides evidence that could justify its traditional use.

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“…The method used by Suliman et al [ 26 ] was used to evaluate the activity of the crude extract on castor oil-induced intestinal fluid accumulation. The mice were assembled and treated in the same way as described above.…”

Section: Methodsmentioning

confidence: 99%

Methanolic Crude Extract of Hagenia abyssinica Possesses Significant Antidiarrheal Effect: Evidence for In Vivo Antidiarrheal Activity

Kifle

Atnafie

Tadesse

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Hagenia abyssinica is one of the most commonly used medicinal plants for the treatment of diarrhea in Ethiopia. Therefore, this study aimed to evaluate the antidiarrheal effect of methanol crude extract of H. abyssinica leaves in mice. Methods. Acute toxicity testing was conducted using Organization for Economic Cooperation and Development guidelines. The antidiarrheal activity of the crude extract of H. abyssinica was investigated using three animal models such as small intestine transit, enteropooling, and castor oil-induced diarrhea models. The extract was administered at three different doses (100, 200, and 400 mg/kg) to the test groups, while the positive control group received 3 mg/kg of loperamide and the negative control group received 10 ml/kg of vehicle (distilled water). Results. The crude extract of H. abyssinica did not exhibit death at the limit dose (2 g/kg) throughout the observation period. In the castor oil-induced model, the crude extract at a dose of 200 and 400 mg/kg exhibited a significant ( P < 0.05 ) antimotility effect as compared to the negative control. The crude extract revealed a significant reduction in the volume and weight of intestinal contents at 200 and 400 mg/kg doses of the extract. Moreover, the highest antidiarrheal index (ADI) was obtained with the dose of 400 mg/kg of crude extract, which was comparable to the standard drug. Conclusion. The crude extract of Hagenia abyssinica possesses antidiarrheal activity and supports the traditional use of H. abyssinica for the management of diarrhea.

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A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions of Terminalia avicennioides in laboratory animal models

Abstract: Graphical abstract

Cited by 40 publications

References 26 publications

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice

Methanolic Crude Extract of Hagenia abyssinica Possesses Significant Antidiarrheal Effect: Evidence for In Vivo Antidiarrheal Activity

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