A Convenient and Concise Metal-Free Approach to Functionalized Bicyclic Pyrimidinones from Oxazine-2,6-diones

Shirsale, Ashwini; Patil, Yogesh; Rawal, Girish K.; Pabba, Jagadish; Berthon, Guillaume; Sonawane, Ravindra P.; Sikervar, Vikas

doi:10.1055/s-0037-1609364

Cited by 2 publications

(1 citation statement)

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“…Oxazine-2,6-diones underwent a reaction with the sodium salt of pyrazolidinone and isoxazolidinone in presence of Hunig's base to form an unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones (Scheme 59). [90] The derivatives furnished are detailed in Table 21. Kokorekin et al developed an effectual atom-economic, chromatography-free and metal-free synthetic route for the preparation of a series of 3-thiocyanatopyrazolo [1,5-a] pyrimidines.…”

Section: Synthesis Of Pyrazolopyrimidine Via Metal-free Conditionsmentioning

confidence: 99%

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

et al. 2021

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Pyrazolopyrimidine with all its isoforms occupy a noteworthy position in medicinal chemistry owing to their proven dominance in the modulation of a vast array of biological receptors, thereby mitigating numerous pathological conditions. The development of sustainable protocols, which integrate the principles of green chemistry in the synthesis process although challenging, offers the most appropriate way to conduct the sustainable synthesis of pyrazolopyrimidines. Due to the effectiveness of this nucleus and striking similarity to purines, they have been accessed using green as well as non-green protocols. Analytical techniques like 2D NMR has been employed for the confirmation of pyrazolopyrimidines and their isomers besides the conventional single-crystal X-ray diffraction (XRD). Here, considering the rising awareness of sustainable protocols, we aimed at exploring this decade for green protocols for the synthesis of pyrazolopyrimidines and furnished products in excellent yields in this review. Protocols covered in this review include synthesis using green solvent, solvent-free conditions, green catalyst, and catalyst-free reactions. Also, synthesis of pyrazolopyrimidines assisted by microwave and ultrasound, as well as ionic liquid mediated synthesis are covered. It is estimated that this review shall throw some light upon the environmentally benign protocols to produce pyrazolopyrimidines which is itself a very important nucleus in the field of medicinal chemistry.

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Section: Synthesis Of Pyrazolopyrimidine Via Metal-free Conditionsmentioning

confidence: 99%

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

et al. 2021

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Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview

Maji

2019

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This review describes the non-exhaustive scenery of the synthesis of various biologically interesting pyrimidine annulated five-membered heterocyclic ring systems that have been appeared in the literature during the last two decades. During this period, different synthetic routes and various methodologies have been developed for the functionalization of pyrimidine ring towards the construction of five-membered heterocyclic rings. The aim of this review is to give an overview of the assorted methodologies that have been reported about the chemistry of construction of pyrimidines annulated nitrogen, oxygen and sulphur containing five-membered heterocycles.

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A Convenient and Concise Metal-Free Approach to Functionalized Bicyclic Pyrimidinones from Oxazine-2,6-diones

Cited by 2 publications

References 7 publications

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview

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