A convenient one pot synthesis of highly substituted piperidines through a Michael addition-aldol cyclization sequence

An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main advantages of the procedure are mild conditions, short reaction times (30–45 min), and high yields (73–83 %).Graphical Abstract

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Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions

Jianguo

Shi

Liu

et al. 2013

Monatsh Chem

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Sulfated titania (TiO2-SO42−) as an efficient and reusable solid acid catalyst for the multi-component synthesis of highly functionalized piperidines

Geetha

Thangamani

Valliappan

et al. 2020

Chemical Data Collections

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In-depth insight into the adsorption mechanism of the piperidine-based inhibitors for excellent corrosion performance: Electrochemical and computational evaluation

El-Haitout,

Salghi,

Chafiq

et al. 2025

Journal of Molecular Structure

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A convenient one pot synthesis of highly substituted piperidines through a Michael addition-aldol cyclization sequence

Abstract: A neat and rapid procedure is reported for the synthesis of a variety of (2-aroyl-5-hydroxy-1,3,5-triaryl-4-piperidyl)(aryl)methanone (3a-3g) by the condensation of 2-[(2-oxo-2-arylethyl)anilino]-1-aryl-1-ethanones 1 with different arylidene acetophenone 2 under microwave irradiation.

Cited by 10 publications

References 14 publications

Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions

Ultrasound-mediated synthesis of N,N-bis(phenacyl)aniline under solvent-free conditions

Sulfated titania (TiO2-SO42−) as an efficient and reusable solid acid catalyst for the multi-component synthesis of highly functionalized piperidines

In-depth insight into the adsorption mechanism of the piperidine-based inhibitors for excellent corrosion performance: Electrochemical and computational evaluation

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