A convenient route for synthesis and antimicrobial evaluation of bis (diimino benzothiazolo pyrimido pyrimidines)

Abstract

Pyrimido pyrimidine and its derivatives are interesting class of nitrogen containing heterocyclic compounds which are widely found in bio-organic and medicinal chemistry with application in drug discovery. Pyrimido [4,5-d] ABSTRACTGuanidine hydrochloride (1) on treatment with bis(methylthio)methylene malononitrile (2) in N,N-dimethyl formamide (DMF) and catalytic amount of anhydrous potassium carbonate gives diimino pyrimido pyrimidine (3). The later were further reacted with various substituted 2-amino benzothiazoles (4) to gives bis (diimino benzothiazolo pyrimido pyrimidines) (5a-g). All these synthesized compounds were screened for their antimicrobial activity.