A coumarin-based fluorescent probe for NIR imaging-guided photodynamic therapy against <i>S. aureus</i>-induced infection in mouse models

Li, Jun; Tu, Le; Ouyang, Qingying; Yang, Sheng-Gang; Liu, Xiao; Zhai, Qianqian; Sun, Yao; Yoon, Juyoung; Teng, Huai‐Long

doi:10.1039/d1tb02723a

Cited by 21 publications

(10 citation statements)

References 44 publications

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“…The synthetic route of probe DJM shows in Scheme S1,† the final steps are as follows: compound 1 and compound 2 were synthesized according to the previous methods. 26,27 The detailed information of instruments used in this work were provided in ESI †…”

Section: Methodsmentioning

confidence: 99%

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Fu,

He,

Jiang

et al. 2023

RSC Adv.

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Section: Methodsmentioning

confidence: 99%

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Fu,

He,

Jiang

et al. 2023

RSC Adv.

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“…Xanthene-coumarin conjugated hybrid fluorophores. [41][42][43][44][45][46][47][48][49][50][51][52] phores (38 and 39) with a large Stokes shift, [51] which provides an solution to improve the small Stokes shift of the hybrid fluorophores.…”

Section: Xanthene-coumarin Conjugated Hybrid Fluorophoresmentioning

confidence: 99%

Rational Design and Biological Application of Hybrid Fluorophores

Zhang,

Qu,

Zhang

et al. 2024

Chemistry A European J

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Fluorophores are considered powerful tools for not only enabling the visualization of cell structures, substructures, and biological processes, but also making for the quantitative and qualitative measurement of various analytes in living systems. However, most fluorophores do not meet the diverse requirements for biological applications in terms of their photophysical and biological properties. Hybridization is an important strategy in molecular engineering that provides fluorophores with complementarity and multifunctionality. This review summarizes the basic strategies of hybridization with four classes of fluorophores, including xanthene, cyanine, coumarin, and BODIPY with a focus on their structure‐property relationship (SPR) and biological applications. This review aims to provide rational hybrid ideas for expanding the reservoir of knowledge regarding fluorophores and promoting the development of newly produced fluorophores for applications in the field of life sciences.

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“…[168] Furthermore, other unconventional classes of photosensitizers have also emerged in APDT and being employed in treating skin and wound infections. These classes include organic dyes [61,166,[172][173][174] and aggregated-induced emission luminogens. [73,[175][176][177][178] As shown in Figure 4C, Li and his coworkers developed a bacterial metabolic labeling photosensitizer that achieve a synergistic photothermal/photodynamic effect with good biocompatibility.…”

Section: Chronic Wound Infections and Skin Infectionsmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Xin

Kwek

et al. 2023

ChemPlusChem

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The emergence of multi‐drug resistant bacteria strains has been an uphill battle in modern healthcare worldwide, due to the increasing difficulty of killing them. The evolving pathogenicity of bacteria has led to researchers searching for more effective antimicrobial therapeutics to successfully eliminate them without undesirable consequences to the human body. In recent years, antimicrobial photodynamic therapy (APDT), an obsolete technique for cancer treatments, has been reported to eradicate bacteria and biofilm‐related infections. The principle of antimicrobial photodynamic therapy solely relies on the photosensitizers (PSs) generating reactive oxygen species, in the presence of oxygen and light, to destroy pathogens. Thus, it can target a broad spectrum of microorganisms, owing to the indirect interaction between PSs and the bacteria, resulting in the less likelihood for the development of drug resistant bacteria strains. This review will focus on the recent progress of APDT in the last five years and some future perspectives of APDT. The mechanism of APDT against bacteria and biofilms, various PSs used for APDT, and some common multidrug‐resistant bacteria strains will be briefly introduced. The reported in vivo applications of APDT in the several types of bacterial infections that includes periodontitis, wound infections, keratitis, endophthalmitis and tuberculosis in the last five years will be summarized in detail.

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A coumarin-based fluorescent probe for NIR imaging-guided photodynamic therapy against S. aureus-induced infection in mouse models

Abstract: A coumarin based and viscosity responsive fluorescent probe (HZAU800) was designed and synthesized. The probe, containing a strong electron-donating and rigid group on 7-position of coumarin, and a rhodamine derivative...

Cited by 21 publications

References 44 publications

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Rational Design and Biological Application of Hybrid Fluorophores

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

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