A critical look at the importance, prevalence and control of toxocariasis and the possibilities of immunological control

Barriga, Omar O.

doi:10.1016/0304-4017(88)90126-4

Cited by 136 publications

(108 citation statements)

References 94 publications

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“…Toxocarosis is highly prevalent in many parts of the world, and 2-18% of the human population carry Toxocara spp. larval infection, as has been shown in several seroprevalence studies (Barriga, 1988). Different populations may have significant differences in seroprevalence depending on the extent of exposure to the infection.…”

mentioning

confidence: 73%

“…Usually the infection in dogs is limited to puppyhood, and older dogs do not excrete Toxocara eggs, although they may carry larval infection. In female dogs silent larvae may lie dormant for years in the tissues and again become mobilised in the latter part of pregnancy, resulting in almost hundred percent prenatal infection in puppies (Barriga, 1988). This phenomenon does not occur in cats (Coati et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…High prevalence (99.4%) of T. canis infection in newborn puppies is connected with the intrauterine transmission route (Barriga, 1988). Tracheal larval migration occurs in puppies, but in adult animals it is almost entirely replaced by somatic migration.…”

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confidence: 99%

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Distribution of Toxocara infection in the environment and in definitive and paratenic hosts in Estonia

Talvik

Moks

Mägi

et al. 2006

Acta Veterinaria Hungarica

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The aim of the study was to elucidate the distribution and possible transmission routes of Toxocara spp. infection in Estonia. Out of 454 faecal and sand samples collected from park lawns and sandpits in the town of Tartu, 19 were Toxocara positive (4.2%). Out of the 45 sandpit samples 17.8% were Toxocara positive. Cat faeces was found in 21 sandpit samples. Parasitological necropsies were performed on 41 euthanised stray dogs and 27 cats in the Tallinn Dog Home. Additionally, 13 wild free-roaming brown rats (Rattus norvegicus) were captured from the Tallinn Dog Home territory, necropsied and studied for the presence of Toxocara larvae. Toxocara canis adults were found in 14.6% of the dogs and Toxocara cati (syn. mystax) adults in the small intestines of 48.2% of the cats examined. Larval infection was detected in the kidney and liver in 5 dogs (12.2%). Our study demonstrated only low-level larval Toxocara infections in adult dogs. Toxocara larvae were not found in cats and brown rats. According to the results of this study, cats more often carry Toxocara infection than dogs. Under our conditions, stray and free-roaming cats are the main contaminators of the environment with Toxocara eggs. Children playing in sandpits are the main risk group for larval toxocarosis.

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confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Distribution of Toxocara infection in the environment and in definitive and paratenic hosts in Estonia

Talvik

Moks

Mägi

et al. 2006

Acta Veterinaria Hungarica

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“…The prevalence of infection of dogs with adult Toxocara worms was reported to be about 25 per cent in Western countries (Barriga, 1988), while the rate in cats in France was 30 to 60 per cent (Petithory et al, 1996). The prevalence of infection tends to decrease with increasing age of the animal and is lower in well-cared pet dogs than in stray or pound dogs.…”

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confidence: 99%

Highlights of human toxocariasis

et al. 2001

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“…Esta situación pone en evidencia el riesgo actual que ofrece el nematodo patógeno T. canis para la salud pública colombiana. La infección por T. canis en perros es de distribución mundial y su prevalencia varía entre 0 y 99,4 %, dependiendo de la ubicación geográfica (11,13,14). Las tasas de seroprevalencia en humanos en América Latina oscilan entre 2,5 y 63,2 % (15-20).…”

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Producción y evaluación del antígeno recombinante Tes-30 de Toxocara canis para el inmunodiagnóstico de toxocariasis

Olave¹,

Mesa²,

Castaño³

et al. 2015

biomedica

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: desarrollo de experimentos Jorge H. Botero: asesoría en el análisis estadístico Edwin B. Patiño: asesoría en la purificación de proteínas Juan F. Alzate: coordinación general del proyecto Todos los autores participaron en la escritura del manuscrito. Producción y evaluación del antígeno recombinante TES-30 deToxocara canis para el inmunodiagnóstico de toxocariasis Introducción. Toxocara canis es un nematodo patógeno de cánidos que accidentalmente puede ser transmitido a los humanos. A pesar de la importancia de la serología para el diagnóstico de esta zoonosis, los kits diagnósticos usan antígenos crudos de excreción-secreción, en su mayoría glucoproteínas que no son específicas de especie, por lo cual pueden presentarse reacciones cruzadas con anticuerpos generados contra otros parásitos. Objetivos. Producir el antígeno recombinante TES-30 de T. canis y evaluarlo para el inmunodiagnóstico de la toxocariasis. Materiales y métodos. Se clonó el gen que codifica TES-30 en el vector de expresión pET28a (+), usando oligonucleótidos de cadena sencilla unidos mediante reacción en cadena de la polimerasa (PCR). La proteína rTES-30 se purificó por cromotografia de afinidad (Ni 2+ ). La reacción serológica de rTES-30 se evaluó mediante immunoblot. Teniendo en cuenta que no existe una prueba de referencia, se observó el comportamiento del antigeno en comparación con la prueba de rutina para el inmunodiagnóstico de la toxocariasis, es decir, la técnica ELISA convencional con antígenos de excreción-secreción.Resultados. El rTES-30 se produjo a partir de un cultivo de Escherichia coli LB, con un rendimiento de 2,25 mg/l y 95 % de pureza. La concordancia de la reacción entre el immunoblot rTES-30 y la ELISA convencional, fue de 73 % (46/63) y de 100 % con los 21 sueros no reactivos. De los 21 sueros con diagnóstico de otras parasitosis, 19 fueron reactivos con ELISA, mientras que tan solo siete fueron positivos con el immunoblot rTES-30. La concordancia entre la ELISA y el immunoblot fue moderada (índice kappa de 0,575; IC 95% 0,41-0,74). Conclusiones. Los datos presentados respaldan la utilidad del immunoblot rTES-30 para la confirmación de los posibles positivos por ELISA, no solo en los estudios epidemiológicos, sino también, como candidato para el desarrollo de pruebas diagnósticas de la toxocariasis ocular en Colombia.Palabras clave: Toxocara canis, toxocariasis/diagnóstico, antígeno, pruebas inmunológicas.doi: http://dx.doi.org/10.7705/biomedica.v36i1.2617 Production and evaluation of the recombinant antigen TES-30 of Toxocara canis for the immunodiagnosis of toxocariasisIntroduction: Toxocara canis is a pathogenic nematode of canines which can be accidentally transmitted to humans. Although serology is the most important diagnostic tool for this zoonosis, diagnostic kits use crude excretion/secretion antigens, most of them being glycoproteins which are not species-specific and may cross-react with antibodies generated against other parasites. Objectives: To produce the rTES-30 recombinant antigen of Toxocara canis and...

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A critical look at the importance, prevalence and control of toxocariasis and the possibilities of immunological control

Cited by 136 publications

References 94 publications

Distribution of Toxocara infection in the environment and in definitive and paratenic hosts in Estonia

Distribution of Toxocara infection in the environment and in definitive and paratenic hosts in Estonia

Highlights of human toxocariasis

Producción y evaluación del antígeno recombinante Tes-30 de Toxocara canis para el inmunodiagnóstico de toxocariasis

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