A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health

Thompson, Darrin A.; Lehmler, Hans‐Joachim; Kolpin, Dana W.; Hladik, Michelle L.; Vargo, John D.; Schilling, Keith E.; Lefèvre, Grégory; Peeples, Tonya L.; Poch, Matthew C.; LaDuca, Lauren Elizabeth; Cwiertny, David M.; Field, R. William

doi:10.1039/c9em00586b

Cited by 255 publications

(221 citation statements)

References 265 publications

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“…Due to their difficulty to penetrate the blood-brain barrier, they should exert low toxicity in vertebrates. However, different direct, indirect, and suspect toxic effects of these compounds on vertebrate wildlife and human health have been reported [16][17][18]. Neonicotinoids were introduced in the market in the 1990s, therefore their sales volume has enormously proliferated in recent decades, exceeding 25% of the market in 2010 [19].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

Zhang

Schilirò²,

Gea³

et al. 2020

IJERPH

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The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradiol, thiacloprid and imidacloprid induced an estrogenic activity at the highest concentrations tested with a relative potency of 5.4 × 10−10 and 3.7 × 10−9, respectively. Molecular dynamics and docking simulations predicted the potential binding sites and the binding mode of the three pesticides on the structure of the two key targets, providing a rational for their mechanism as EDCs. The results demonstrate that the three pesticides are potential EDCs as glyphosate acts as an aromatase inhibitor, whereas imidacloprid and thiacloprid can interfere with estrogen induced signaling.

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Section: Introductionmentioning

confidence: 99%

“…In particular, mounting evidence discloses that exposure to pesticides can affect the endocrine system. Toxicological and epidemiological studies indicate possible genotoxic and cytotoxic effects as well as birth defects and neurotoxicity in different cell lines and animal models [18,30].…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

Zhang

Schilirò²,

Gea³

et al. 2020

IJERPH

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“…Neonicotinoids were developed to replace older and more harmful insecticides. [1][2][3] They are one of the most popular and widely used insecticides in the world. [1][2][3] Many synthetic neonicotinoids are currently marketed including acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] They are one of the most popular and widely used insecticides in the world. [1][2][3] Many synthetic neonicotinoids are currently marketed including acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam. 1,3 Among these, imidacloprid is the most commonly used.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Many synthetic neonicotinoids are currently marketed including acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam. 1,3 Among these, imidacloprid is the most commonly used. 1,3 Imidacloprid functions as a nicotinic acetylcholine receptor (nAChR) agonist, particularly for the α4β2 subtype, and induces neuromuscular paralysis and death in insects.…”

Section: Introductionmentioning

confidence: 99%

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<p>Acute Imidacloprid Poisoning in Thailand</p>

Sriapha

Trakulsrichai

Tongpoo

et al. 2020

TCRM

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Introduction Imidacloprid is the most commonly used neonicotinoid insecticide worldwide. Despite its reputation for safety, there is increasing evidence regarding its toxicity. This study characterized the clinical manifestations and outcomes of acute imidacloprid poisoning. Methods This was a retrospective study of patients with imidacloprid poisoning who were referred to the Ramathibodi Poison Center in Bangkok, Thailand between 2010 and 2018. Results A total of 163 patients with imidacloprid-only exposure were included. Most were exposed by ingestion (93.3%). The patients were predominantly male (55.8%), with a median age of 41.3 years. The common presenting features were gastrointestinal symptoms (63.8%) with no corrosive injuries and neurological effects (14.2%). The majority of medical outcomes was no (18.4%) to mild (76.1%) toxicity. One patient had symptoms mimicking cholinergic syndrome, three developed liver injury, and five died. Among the five deaths, two patients presented severe initial severity, and one presented moderate initial severity. Two of the patients who died initially presented only mild severity. The mortality rate was 3.1%. The estimated amount of ingestion, cardiovascular effects (especially tachycardia and cardiac arrest), central nervous system effects (especially coma), dyspnea, and diaphoresis were significantly associated with mortality. Patient management primarily included supportive and symptomatic care. Conclusion Most patients with imidacloprid poisoning developed only mild toxicity. The mortality rate was low, but a few patients with mild initial severity died. Patients who ingest a large amount or show these warning signs including cardiovascular effects, central nervous system effects, dyspnea, and diaphoresis at the initial presentation should be considered for close observation and monitoring.

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Photoelectrochemical Clothianidin Detection Based on a WO₃/CdS Heterostructure Coated with a Molecularly Imprinted Thin Film

et al. 2022

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Clothianidin is an effective neonicotinoid insecticide and is harmful to human health. It is urgent to develop convenient analytical methods to determine clothianidin. In this study, a label‐free photoelectrochemical (PEC) sensor for clothianidin was proposed. A type‐II WO3/CdS heterojunction was prepared by chemical bath deposition method to enhance the photoelectric response. As a recognition element, the molecular imprinted polymer (MIP) film was formed on WO3/CdS by electropolymerization of o‐phenylenediamine functional monomer in the presence of clothianidin template. Owing to the high photoelectric conversion efficiency of WO3/CdS heterostructure and the specific recognition ability of MIP, the as‐prepared PEC sensor exhibits desirable analysis performance for clothianidin with high sensitivity and selectivity. This MIP‐PEC sensor offers a wide linear detection range from 1.0 nM to 5.0 μM with a detection limit of 0.4 nM. The proposed sensor combines the merits of MIP and semiconductor heterojunction, presenting a promising prospect in the field of analysis.

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A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health

Abstract: The review examines literature relevant to environmental fate, transformation, and toxicity, and human exposure and health risks of neonicotinoid insecticides.

Cited by 255 publications

References 265 publications

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

<p>Acute Imidacloprid Poisoning in Thailand</p>

Photoelectrochemical Clothianidin Detection Based on a WO₃/CdS Heterostructure Coated with a Molecularly Imprinted Thin Film

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A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health

Abstract: The review examines literature relevant to environmental fate, transformation, and toxicity, and human exposure and health risks of neonicotinoid insecticides.

Cited by 255 publications

References 265 publications

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

<p>Acute Imidacloprid Poisoning in Thailand</p>

Photoelectrochemical Clothianidin Detection Based on a WO3/CdS Heterostructure Coated with a Molecularly Imprinted Thin Film

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Product

Resources

About

Photoelectrochemical Clothianidin Detection Based on a WO₃/CdS Heterostructure Coated with a Molecularly Imprinted Thin Film