A cross-linked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits

Abstract

Chemically modified and cross-linked derivative of hyaluronan improved corneal wound healing and could be useful for treating noninfectious corneal injuries.

Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel

“…Thus, crosslinked CMHA-S would act as a local lubricant as well as a highly biocompatible vehicle to deliver drugs in a sustained manner with less frequent ocular administration. 13,33,34 Such drugs may include growth factors or small molecules to stimulate Figure 1. An example of crosslinking thiol-modified carboxymethyl hyaluronic acid (CMHA-with thiol-modified gelatin) (Gtn-DTPH) using the bifunctional crosslinker poly(ethylene glycol) diacrylate (PEGDA) to form a thioether crosslinked semi-synthetic matrix (CMHA-GSX).…”

“…21,22 CMHA-S films and gels have already been shown effective in vivo for the treatment of injured vocal folds, scar-free healing after endoscopic sinus surgery, preventing stenosis after tracheal injury, preventing postsurgical adhesions, and treating skin and corneal wounds in various animal models. 13,14,[23][24][25][26][27] Further, this material releases encapsulated growth factors slowly over timescales of weeks to months both in vitro and in vivo. 28,29 For example, wound healing was accelerated in various disease and injury models when growth factors were continuously released from topical hydrogels as films and gels into full-thickness wounds.…”

Hyaluronic acid covers in burn treatment: a systematic review

“…In experimental studies, hyaluronic acid demonstrates superiority compared to other covers, with respect to shorter time of wound healing and histological characteristics such as improved elasticity and higher microvascular density (29)(30) . When hyaluronic acid is applied in wounds, there is improved water retention, which favors a suitable environment for the formation of collagen and elastin, and allows the cells to proliferate and differentiate, accelerating the healing process (31) .…”

Topical 1% Nalbuphine on corneal sensivity and epitheilization after experimental lamellar keratectomy in rabbits

“…Images were taken with a digital camera (Cybershot 7.1 ® Sony do Brasil, São Paulo, SP, Brasil) at a fixed distance of 10cm and the dimensions of the wound areas were measured using an image analysis software (Image J, rsbweb.nih.gov/ij/). The percentage of the wound area was calculated as described previously (YANG et al, 2010).…”