A cross-sectional hospital based study of clinical and immunological profile of systemic lupus erythematosus patients from central rural India

Agrawal, Sachin; Tiewsoh, Iadarilang; Rajput, Atulsingh; Jain, Ajit Prasad

doi:10.4103/0972-6691.116614

Cited by 11 publications

(36 citation statements)

References 8 publications

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“…This was in concordance with a study by Agarwal et al [10] who also reported fever as the most common presenting symptom accounting to 82.8%. The incidence of arthritis in the present study was in concordance with the studies by Voulgareli et al [8] (50%), Fathi et al [9] (60%), Agarwal et al [10] (52.9%) and Kosaraj et al [14](64.58%).…”

Section: Discussionsupporting

confidence: 93%

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A study to assess the clinic pathological profile of patients with systemic Lupus Erythematosus

Patil

2019

Trop J Pathol Microbiol

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Background: Systemic lupus erythematosis (SLE) is a multisystemic chronic autoimmune disorder predominantly affecting women of child bearing age. The diverse clinical course and a high prevalence of SLE make it a major cause of morbidity and mortality especially in the younger population. Objective: To study the clinic Pathological profile of patients suffering from Systemic Lupus Erythematosus. Methodology: An Ambispective study was conducted at Kasturba Medical College and hospital, Manipal from January 2011 to December 2013. A total of One hundred twenty seven cases of SLE were classified as having SLE according to the revised American College of Rheumatology (ACR) classification criteria (1997). Results: The mean age of the study subjects in the present study was 29.85±12.61years.The male to female ratio was 1:11.7. Fever was the most common presenting symptom of the patients in the present study accounting to 92 out of total 127 cases studied (72.4%), followed by ascitis and skin rashes. Conclusion: SLE is a multisystem disorder affecting predominantly young females. Polyarthritis was the most common clinical feature. Incidence of fever was the most common symptoms followed by dermatological manifestation .Hence all the cases of SLE should be evaluated in detail for the involvement of the all the systems and its manifestations in detail to improve the overall condition of the patients.

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Section: Discussionsupporting

confidence: 93%

“…Similarly, the median age of presentation at 29.5 years in the present study, is also expected as SLE is a disease affecting the women of childbearing age group and hence is in concordance with the other studies [10], [11].. However in the study by Voulgareli et al [8], the mean age was 42yrs, which is much higher than the present study.…”

Section: Discussionsupporting

confidence: 92%

A study to assess the clinic pathological profile of patients with systemic Lupus Erythematosus

Patil

2019

Trop J Pathol Microbiol

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“…Both studies showed that the majority of SLE patients were anaemic, lymphopenic and had a high erythrocyte sedimentation rate and hypo-complimentemia. When comparing SLE manifestations in Oman to the Gulf and other countries, haematological and musculoskeletal manifestations appear to be similar in frequency 1,[10][11][12][13][14][15][16][17] . Renal disease, however, was more common in the Gulf countries and India compared to Europe and Australia.…”

Section: Discussionmentioning

confidence: 99%

“…Renal disease, however, was more common in the Gulf countries and India compared to Europe and Australia. It was recorded in 44%, 37%, 43%, 63% and 69% of the patients in Oman, Kuwait, United Arab Emirates (UAE), Kingdom of Saudi Arabia (KSA) and India respectively [10][11][12][13] . In contrast, renal disease was lower in frequency in Italy, United Kingdom (UK) and Australia.…”

Section: Discussionmentioning

confidence: 99%

“…Neurological diseases manifested in 15%, 23%, 15% and 26% of patients with SLE in Oman, Kuwait, UAE and KSA, respectively 1,10-12 , however, they are less frequently reported in other countries including India. Neurological diseases were reported in 4.5%, 8%, 10% and 16-5% of SLE patients in India, Italy, UK and Australia [13][14][15][16][17] . Anti-ds DNA antibodies and anti-Smith antibodies were more prevalent in Oman and other Gulf countries.…”

Section: Discussionmentioning

confidence: 99%

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Demographic, Clinical and Immunological Manifestations of Systemic Lupus Erythematosus among Omani Population Single Tertiary Care Experience

2018

J Liaquat Uni Med Health Sci

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OBJECTIVES: This study aimed to determine the demographic, clinical and immunological manifestations of SLE among the Omani population and to compare the results with a previous study in 2003and global data. METHODOLOGY: This retrospective study included patients aged >12 years old with SLE who complied with the 2012 Systemic Lupus International Collaborating Clinics SLE criteria and presented to the Sultan Qaboos University Hospital, Muscat, Oman between January-December 2016. The cumulative frequency of disease manifestations and auto antibodies was determined. Published studies evaluating SLE manifestations in other countries (Gulf countries, India, UK, Italy and Australia) were collected for comparison. RESULTS: A total of 285 patients were included in this study, 256 (89.5%) were female and 29 (10.5%) were male with a female: male ratio of 9:1. The median age was 33 years (age range: 14-69). The 10 year survival rate was found to be 99% with 6.8% of patients lost to follow up. More than 60% of the patients were from two highly populated regions: Al Batinah (37%) and Muscat (24%) governorate. The cumulative frequency of the clinical manifestations was as follows: haematological manifestations (63%), arthritis (62%), renal manifestations (44%), serositis (12.3%), alopecia (26.3%), rash (31%), oral ulcers (11.9%) and neurological disorders (15%). The cumulative frequency of the detected auto-antibodies was as follows: anti-nuclear antibodies(98%), anti-double stranded DNA (81%), extractable nuclear antigens (89%), anti-histone (37%), anti-smith (25%), anti-Sjögren's syndrome A (36%), anti-Sjögren's syndrome B(10.6%), anti-nucleosome (35%) and anti-Ribosomal antibodies (23%). CONCLUSION: Comparing the above results to other studies, clinical and immunological manifestations of SLE in Oman are similar to other Gulf countries. There is an increased frequency of visceral (renal and neurological) involvement in the Gulf region compared to other geographic areas around the world.

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A study on hematological and immunological profile of patients with systemic Lupus Erythematosus

Patil

2019

Trop J Pathol Microbiol

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Background: Systemic lupus erythematosus (SLE) is a chronic, relapsing, inflammatory and often febrile multisystem disorder of the connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. Hematological findings may be present at the onset of the disease or can develop during the course of the disease. Since blood and blood vessels together contain more diverse number of antigens than any other organ in the body, it is only natural to expect hematological manifestations more often than the other systems. Objectives: To study the haematological and immunological Profile of Patients with Systemic Lupus Erythematosis. Methodology: An Ambispective study was conducted at Kasturba Medical College and hospital, Manipal from January 2011 to December 2013. A total of One hundred twenty seven cases of SLE were classified as having SLE according to the revised American College of Rheumatology (ACR) classification criteria (1997). Results: Hematological manifestations were frequently seen in the cases studied, which included anemia, neutropenia, lymphopenia, thrombocytopenia, pancytopenia, increased Erythrocyte sedimentation rate (ESR), presence of spherocytes, DCT positivity etc.Anemia was the most common hematological abnormality observed in the patients accounting to 87.4% (111/127) of cases. Hemoglobin of patients varied from a minimum of 3.8g/dl up to 13.5g/dl (Median = 9.6±2.2). The erythrocyte sedimentation rate (ESR) was assessed in all except one.The PCNA (Anti proliferating cell nuclear antigen) antibodies were positive in 44% of the cases. Conclusion: Hematological abnormalities are the commonest among all other manifestations in SLE, and their treatment is challenging. Bone marrow examination should be considered in all cases of severe or persistent leukopenia or thrombocytopenia in SLE, to exclude dug-induced myelotoxicity in susceptible patients.

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A cross-sectional hospital based study of clinical and immunological profile of systemic lupus erythematosus patients from central rural India

Cited by 11 publications

References 8 publications

A study to assess the clinic pathological profile of patients with systemic Lupus Erythematosus

A study to assess the clinic pathological profile of patients with systemic Lupus Erythematosus

Demographic, Clinical and Immunological Manifestations of Systemic Lupus Erythematosus among Omani Population Single Tertiary Care Experience

A study on hematological and immunological profile of patients with systemic Lupus Erythematosus

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