A cross sectional study of HPV type prevalence according to age and cytology

Abstract

BackgroundA cross sectional study to investigate HPV prevalence according to age and cytology.MethodsWomen presenting to a gynaecological outpatient clinic for a Pap smear test were included in the study (n=3177). All women had cervical cytology and HPV testing.ResultsOverall prevalence of any 24 HPV type analysed was 33.1% (95% CI 31.5% to 34.7%) and HPV 16 and HPV 42 were the most frequent (6.7% (95% CI 5.8% to 7.6%), 6.8% (95% CI 5.9% to 7.6%)), in total samples. Multiple HPV infection rate was 12.9% (95% CI 11.8% to 14.1%). High risk HPV (hrHPV) types were present in 27.4% (95% CI 25.8% to 28.9%) of the samples.HPV prevalence was highest among 14 to 19 y.o (46.6% (95% CI 40.7%-52.4%)) and second highest among 30–34 y.o. (39.7%, 95% CI 35.4%–44%). HPV 16 was highest among 20–24 (9.0% (95% CI 6.4%–11.6%)) and second highest among 50 to 54 y.o. (6.3% (95% CI 2.9% to 9.8%).In Low-grade Squamous Intraepithelial Lesions (LgSIL) cytology samples, the most frequently detected hrHPV types were: 16 (14.5% (95% CI 12.1% to 16.9%)), 51 (13.0% (95% CI 10.7% to 15.3%)) and 53 (9.1% (95% CI 7.2% to 11.1%)) and in High-grade Squamous Intraepithelial Lesions (HgSIL) were: HPV 16 (37.2% (95% CI 26.5% to 47.9%)), HPV 51 (17.9% (95% CI 9.4% to 26.5%)) and HPV 18 (12.8% (95% CI 5.4% to 20.2%)).ConclusionsIn the population studied, HPV 16 and 51 were the most frequent detected hrHPV types. HPV positivity, hrHPV and multiple HPV types infections were higher in young women, while HPV prevalence declined with increasing age and presented two peaks a higher (14–19 y.o.) and a lower one (30–34 y.o.) These results may contribute to the creation of a national screening programme.

Prevalence of High Risk Human Papillomavirus Infection with Different Cervical Cytological Features among Women Undergoing Health Examination at the National Cancer Institute, Thailand

“…In addition, many studies reported the prevalence of HPV infection varied according to age group (Coupe et al, 2008, Argyri et al, 2013, however others have not identified a significant relation (Burd 2003). Our results show that the prevalence of HPV infection were similar in all age groups.…”

Use of Fast Transfer Analysis Cartridges for Cervical Sampling and Real Time PCR Based High Risk HPV Testing in Cervical Cancer Prevention - a Feasibility Study from South India

“…Our results showed a significant association between HR HPV prevalence and epithelial abnormalities detected in cervical smears very similar to earlier reports (Argyri et al, 2013;Sarma et al, 2015). The current study detected HPV 16 viral DNA in 50% of LSIL, 75% of HSIL and 100% of SCC.…”

Shift in prevalence of HPV types in cervical cytology specimens in the era of HPV vaccination

“…However, it has been observed that the presence of MT HPV does not affect the severity of infection, and HPV infections are independent of one another (39). In the present study, 43.40% of all HPV + participants were infected with one type of HPV (ST HPV), whereas the majority of participants exhibited MT HPV (56.60%).…”