A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate

Abstract

There was no association between low-level As exposure and general cognitive abilities.

Association of Low Lead Levels with Behavioral Problems and Executive Function Deficits in Schoolers from Montevideo, Uruguay

“…A detailed protocol for the study, including recruitment, has been provided elsewhere [37,38]. Briefly, directors of the schools located in the neighborhoods of interest were contacted to have an interview and obtain permission to invite parents to an informational meeting.…”

“…Concentrations of C-reactive protein (CRP) were measured to identify the presence of subclinical inflammation/infection in the study children. CRP was analyzed in duplicate using an ELISA technique described by Erherdt and colleagues [36,37,38]. Serum control samples (Liquicheck, Bio-Rad, Hercules, CA, USA) were used as standards.…”

Latent subgroups of cognitive performance in lead- and manganese-exposed Uruguayan children: Examining behavioral signatures

“…Our study considered the effects of more than one metal: we elucidated the conjoint relationship between low-level hair Mn and blood Pb on cognitive performance. In another report, we showed that low-level arsenic exposure was not associated with general cognitive abilities in this sample of children (Desai et al, 2018). Our participants underwent an extensive battery of cognitive tests allowing us to examine the effect of Pb and Mn across multiple cognitive domains.…”

Relationships among Inorganic Arsenic, Nutritional Status CpG Methylation and microRNAs: A Review of the Literature

“…31 Moreover, iAs methylation capacity was also not modified by B12. 31,32 The role of methylation capacity in iAs-associated neurotoxicity among children was inconclusive. Further, no evidence of effect modification was observed in the two studies on iAs and neurodevelopment that also included stratification by %MMA.…”

“…31 The efficiency of iAs methylation capacity was identified by percentages of low MMA V , low iAs, and high DMA V and the average urinary arsenic levels were 11.7 μg/L 31 and 11.9 μg/L. 32 Hamadani et al set out to elucidate the critical window of exposure for iAs-associated cognitive impairment within the Matlab, Bangladesh longitudinal population-based cohort where >95% of the population was exposed to water arsenic levels >10 μg/l. 33,34 The researchers assessed the effects of nutrient supplementation during pregnancy as part of a maternal and infant nutrition intervention in Matlab (MINIMat), and children born in the study were recruited to measure child development.…”