A Cross Sectional Study of Oral Submucous Fibrosis in Central India and the Effect of Local Triamcinolone Therapy

Ameer, Nasir; Shukla, Rakesh Kumar

doi:10.1007/s12070-011-0365-9

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The pathogenesis of OSF is complex and still not fully understood. The results of medical and physical therapies for OSF management are shown in Table 3 [28][29][30][31][32][33][34][35] and those of representative surgical therapies are summarized in Table 4. [36][37][38][39][40]…”

Section: Tre Atmentmentioning

confidence: 99%

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Oral submucous fibrosis in Asian countries

Peng

Chen

et al. 2019

J Oral Pathology Medicine

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Oral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. It is precancerous and characterized by blanching and burning sensation of oral mucosa, staining of teeth and gingiva, and restricted mouth opening. It is multifactorial with a high incidence in chewers of areca nut (AN). This oral potentially malignant disorder has a high rate of malignant transformation rate (7%-30%) to oral squamous cell carcinoma (OSCC). 1 It is prevalent in Asian countries and has spread in Europe and North America. The prevalence of OSF was reported to be 1.0%-3.03% in Hunan Province, mainland China, 2 0.15%-14.4% in Vietnam, 3 and 0.086%-17.6% in Taiwan. 4 In the past decades, many efforts have been devoted to etiology, pathogenesis, and treatment of OSF. However, the research progress is still unsatisfactory. For instance, the etiology of OSF is commonly attributed to AN chewing, but some OSF patients did not have the habit. Also, there is no staging or grading scheme universally accepted and employed by clinicians, pathologists, and surgeons. Moreover, the pathogenesis and mechanism of OSF transformation into carcinomas are still obscure. Undoubtedly, it is crucial to make further studies of OSF to fill in the gaps. This article, for the first time, provided a detailed review of research advances of OSF in Asian countries, based on a comprehensive literature search using several primary databases (Figure 1), in which the terminologies, for example, OSF and oral potential malignant diseases (OPMD), were used. The OSF's etiology, histopathology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, and treatments were reviewed. The main challenges and corresponding measures were also discussed for guiding clinical research and practice concerning the disease. | E TI O LO GYOral submucous fibrosis is characterized by its multifactorial etiology. The most commonly identified factors include AN chewing, nutritional disorders, and genetic predisposition. They act individually or synergistically in the development of OSF. AbstractOral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. This oral potentially malignant disorder has a high rate of malignant transformation (7%-30%) to oral squamous cell carcinoma (OSCC), posing global problems for public health. Due to enormous efforts dedicated to this disease in the past decades, there have been significant advances in identification of its etiology and pathogenesis as well as development of corresponding therapeutic approaches, in spite of several challenges. This study reviewed the existing literature concerning OSF in Asian countries, encompassing its etiology, histopathology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, and treatments. For improving treatment of OSF, the multifactorial etiology analysis, incorporation of effective molecular pathways, cy...

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Section: Tre Atmentmentioning

confidence: 99%

“…For the disease at the intermediate or advanced stage, physical and/or surgical therapies are necessary for alleviating symptoms of pain of oral mucosa and for increasing mouth opening. The results of medical and physical therapies for OSF management are shown in Table and those of representative surgical therapies are summarized in Table …”

Section: Treatmentmentioning

confidence: 99%

Oral submucous fibrosis in Asian countries

Peng

Chen

et al. 2019

J Oral Pathology Medicine

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“…In study done by Ameer and others, significant improvement in mouth opening is observed following local triamcinolone injection therapy. 13 Out of 50 patients in this study, treated 21 (42%) patients showed increase in mouth opening of greater than 11 mm and 19 (38%) patients showed an increase of 6-10 mm and the rest patients showed an increase of less than 5 mm.…”

Section: Discussionmentioning

confidence: 62%

Medical management of oral submucous fibrosis

Agrawal

Kaushal

Vaidya

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: In 1952 Schwartz coined the term “atrophica idiopathica mucosa oris” to describe an oral fibrosing disease he discovered in 5 Indian women from Kenya. Oral submucous fibrosis of oral cavity is a chronic progressive debilitating disease and premalignant condition of oral cavity. The condition is well recognized for its malignant potential and it is particularly associated with aracanut chewing. It is characterized by burning sensation in mouth particularly while eating spicy food and progressive development of inability to open mouth. Worldwide estimate of oral submucous fibrosis indicate that 2.5 million people are affected with a higher incidence in Indian subcontinent. Methods: This is an observational type of study of 100 patients with oral submucous fibrosis attending ENT OPD. Results: We observed that with effective combination of treatment and avoiding predisposing factors and with long time follow-up we got markedly good results. Conclusions: Although medical management does not completely cure the disease but optimal doses of injection corticosteroid with injection hyaluronidase with avoidance of predisposing factors and improvement of dietary habit with prolong follow up is effective in some extent.

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“…Some clinicians also advise the use of intralesional injections with steroids to improve mouth opening of the patient. In a study conducted by (Ameer and Shukla, 2012;Ajay et al, 2017) it was observed that intralesional injections with triamcinolone in OSMF patients by giving biweekly submucosal injections of 40 mg triamcinolone for 12 weeks, patients subjectively showed improvement in symptoms and objectively increase in mouth opening was observed. However, such modalities have drawbacks too.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and management of oral submucous fibrosis and its implications on prosthodontic treatment: A retrospective study

Agarwal¹,

Maiti²

2020

ijrps

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Oral submucous fibrosis is a chronic, premalignant condition that is prevalent in Asian countries like India, Pakistan and Srilanka. Oral cancer accounts for around 30% of the cancer cases in India. It is important to understand the prevalence of the disease for its effective management. The aim of the study was to understand the prevalence of the condition and the popularity of various treatment modalities used in its management, along with the prevalence of OSMF patients requiring prosthetic rehabilitation. Case sheets of around 23,000 patients were reviewed from March 2019 to June 2020 out of which 100 patients were affected by oral submucous fibrosis. To eliminate bias, all patients affected by the disease were included in the study. Epidemiological data of the patient along with their ongoing treatment, was collected and tabulated in MS Excel sheet. The data was then analyzed using IBM SPSS software version 23: The prevalence of OSMF in males was 92% while in females, it was 8%. The age group of 31-40 years was found to be most commonly affected, and pan chewing was observed to be the most common abusive habit amongst OSMF patients. The most common treatment modality used was non-invasive methods within which antioxidant therapy was the most popularly used modality. The increasing prevalence of OSMF amongst the younger population is a matter of great concern. The present study shows the prevalence of OSMF in males, especially in the young and middle-aged population. Thus it is important to increase awareness amongst the youth regarding the condition and to increase awareness amongst the dentists regarding the various treatment modalities to effectively prevent and clinically manage such conditions.

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A Cross Sectional Study of Oral Submucous Fibrosis in Central India and the Effect of Local Triamcinolone Therapy

Cited by 4 publications

References 8 publications

Oral submucous fibrosis in Asian countries

Oral submucous fibrosis in Asian countries

Medical management of oral submucous fibrosis

Prevalence and management of oral submucous fibrosis and its implications on prosthodontic treatment: A retrospective study

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