A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant–antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease

Sahebkar, Amirhossein; Pourghadamyari, Hossein; Moohebati, Mohsen; Parizadeh, Seyed Mohammad Reza; Falsoleiman, Homa; Dehghani, Mahboobe; Fazlinezhad, Afsoon; Akhlaghi, Saeed; Tavallaie, Shima; Paydar, Roghayeh; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1016/j.clinbiochem.2011.09.011

Cited by 23 publications

(10 citation statements)

References 45 publications

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“…The existence of AAB against HSPs in the context of atherosclerosis is not new – for example, antibodies generated against microbial HSP60 may cross-react with endogenous HSP60 expressed in the vessel lumen (molecular mimicry), enhancing inflammation and promoting atherosclerosis ( 173 ). HSP27 AAB are present in other disease states like cancer ( 174 ) and acute heart disease ( 175 – 177 ), although it is difficult to gage how levels correlate with disease. Higher antibody titers are associated with improved survival of breast cancer patients, but elevations also correlate with adverse conditions, such as metabolic syndrome ( 177 ) and the early phase of acute coronary syndromes (e.g., myocardial infarction and unstable angina) – although in acute coronary syndromes, HSP27 antibody levels rapidly fall after a brief spike ( 175 ).…”

Section: Future Directionsmentioning

confidence: 99%

“…HSP27 AAB are present in other disease states like cancer ( 174 ) and acute heart disease ( 175 – 177 ), although it is difficult to gage how levels correlate with disease. Higher antibody titers are associated with improved survival of breast cancer patients, but elevations also correlate with adverse conditions, such as metabolic syndrome ( 177 ) and the early phase of acute coronary syndromes (e.g., myocardial infarction and unstable angina) – although in acute coronary syndromes, HSP27 antibody levels rapidly fall after a brief spike ( 175 ). It is still unclear how HSP27 AAB are linked to CVD – one study correlated elevations with CVD ( 176 ), while other findings indicate the opposite, that HSP27 autoantibody titers ( 67 , 178 ) are higher in healthy control subjects compared to CVD patients.…”

Section: Future Directionsmentioning

confidence: 99%

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Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

et al. 2016

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Heat shock protein 27 (HSP27) is traditionally viewed as an intracellular chaperone protein with anti-apoptotic properties. However, recent data indicate that a number of heat shock proteins, including HSP27, are also found in the extracellular space where they may signal via membrane receptors to alter gene transcription and cellular function. Therefore, there is increasing interest in better understanding how HSP27 is released from cells, its levels and composition in the extracellular space, and the cognate cell membrane receptors involved in effecting cell signaling. In this paper, the knowledge to date, as well as some emerging paradigms about the extracellular function of HSP27 is presented. Of particular interest is the role of HSP27 in attenuating atherogenesis by modifying lipid uptake and inflammation in the plaque. Moreover, the abundance of HSP27 in serum is an emerging new biomarker for ischemic events. Finally, HSP27 replacement therapy may represent a novel therapeutic opportunity for chronic inflammatory disorders, such as atherosclerosis.

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Section: Future Directionsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

et al. 2016

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“…An in‐house ELISA assay was applied to determine serum anti‐Hsp27 levels as described previously (Sahebkar et al ., ). In brief, microtitre plates were coated with recombinant human Hsp27.…”

Section: Methodsmentioning

confidence: 97%

“…Hsp27 is a member of the small Hsp family that is constitutively expressed in many cell types including cardiomyocytes and endothelial cells (Tucker et al ., ; Gernold et al ., ; Pauli et al ., ). Several investigations have reported an elevation of circulating levels of Hsp27 and its corresponding antibodies (anti‐Hsp27) with coronary artery disease (CAD) (Pourghadamyari et al ., ), acute coronary syndrome (ACS) (Heidari‐Bakavoli et al ., ; Ghayour‐Mobarhan et al ., ) and metabolic syndrome (Sahebkar et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Curcuminoids Modulate Pro‐Oxidant–Antioxidant Balance but not the Immune Response to Heat Shock Protein 27 and Oxidized LDL in Obese Individuals

Sahebkar

Mohammadi

Atabati

et al. 2013

Phytotherapy Research

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148

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Curcuminoids have potentially important functional qualities including anti-inflammatory and antioxidant properties. In this randomized double-blind placebo-controlled cross-over trial, the effects of a curcuminoid supplement on serum pro-oxidant-antioxidant balance (PAB) and antibody titres to Hsp27 (anti-Hsp27) and oxLDL (anti-oxLDL) were investigated. Thirty obese individuals were randomized to receive either curcuminoids (1 g/day) or placebo for a period of 30 days. After a wash-out period of 2 weeks, subjects were crossed over to the alternate regimen for another 30 days. Serum PAB along with anti-Hsp27 and anti-oxLDL titres was measured at the beginning and at the end of each study period. There was no significant carry-over effect for any of the assessed parameters. Curcuminoid supplementation was associated with a significant decrease in PAB (p = 0.044). However, no significant change was observed in serum concentrations of anti-Hsp27 or anti-oxLDL (p > 0.05). These findings suggest that oral curcuminoids supplementation (1g/day) is effective in reducing oxidative stress burden, though this needs to be validated in larger study populations.

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“…An in-house ELISA assay was used to quantify serum anti-Hsp27 levels as described previously (Sahebkar et al, 2011). Briefly, serum was diluted with 2% goat serum in PBS was added to microplates which were coated with recombinant human HSP27.…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Anemia is associated with cognitive impairment in adolescent girls: A cross-sectional survey

Bahrami

Khorasanchi

Tayefi

et al. 2019

Applied Neuropsychology: Child

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Anemia is associated with impairment in oxygen transport, affecting an individual's physical and mental wellbeing, and work performance. The aim of this study was to examine the prevalence of anemia and its possible association with serum antibody titers to Hsp27 (as an indicator of cellular stress), cognitive function, measures of emotion, sleep patterns in adolescent girls. A total of 940 adolescent girls were assessed to evaluate neuropsychological function with validated questionnaires. A complete blood count was determined as part of the assessment of hematological parameters. Serum anti-Hsp27 was measured for each subject. Among the total of 940 participants, 99 girls (10.5%) were anemic [hemoglobin <12(g/dl)]. Serum anti-HSP27 was significantly higher in anemic compared to healthy girls (p<0.05). There was no significant differences in depression, aggression, insomnia, daytime sleepiness and sleep apnea score between two groups. However, the total cognitive abilities score was significantly lower in the anemic girls (76.8±2.1 versus 85.7±2.5, p = 0.002). Logistic regression analysis showed that anemic girls were 1.73 times more likely than non-anemic girls to have cognitive impairment (95% confidence interval [CI] = 1.07-2.78; P = 0.025). Anemia was associated with elevated levels of anti-HSP27 and supports the hypothesis that cellular stress may be associated with anemia. Anemia was adversely associated with an assessment of cognitive abilities and was an independent risk factor for cognitive impairment in this group.

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A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant–antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease

Cited by 23 publications

References 45 publications

Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

Curcuminoids Modulate Pro‐Oxidant–Antioxidant Balance but not the Immune Response to Heat Shock Protein 27 and Oxidized LDL in Obese Individuals

Anemia is associated with cognitive impairment in adolescent girls: A cross-sectional survey

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