A cross sectional study to evaluate the relation between thyroid disorders and abnormal uterine bleeding in reproductive age group

Verma, K. S.; Verma, Susheel; Rajoria, Lata

doi:10.18231/j.ijogr.2019.041

Cited by 2 publications

(5 citation statements)

References 8 publications

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“…. Similar flux of population was reported in a study in which the majority of females presented with AUB were euthyroid (77%) and 23% were affected with thyroidism, while, our findings revealed that 71.87% AUB patients were euthyroid and 28.13% were affected with thyroid disorders 3,14,15 . Similar findings were reported that most patients presented with AUB were from category of euthyroid and the menorrhagia was the common matter of complain 16 .…”

Section: Examination Of the Patientssupporting

confidence: 90%

“…The association of thyroidism was also compared with AUB incidence in different age groups of the females and it was evident from the results that significantly highest (p<0.05) incidence of AUB due to thyroid abnormities was seen in the age Group C (39-50 years) (78.57%) and Group A (13-25 years) (38.15%), while, 4). The findings of our study were in accordance with the studies in which the prevalence of AUB due to thyroid disorders was highest in old age females 3,13 . Another study stated that 67.2% of the female patients of age 35-45 years were affected with AUB due to thyroid disorders 17,18 .…”

supporting

confidence: 92%

“…While, the females complaining AUB with known thyroid problems, blood clotting or coagulopathy, were excluded from the study. All those women who were already diagnosed with the uterine polyps, fibroid, cancers, ovarian cysts, cervical tumors, malignancy, or enometriosis were also excluded from the study recruitment 3 .…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…It is the most common clinical presentation in the gynecology, affecting more than 20% female population and is the bleeding from uterus clinically characterized by variations from the normal menstruation pertaining to the irregularity in periods, frequency, duration of blood flow, extent of blood loss and cyclicity 2 . It can be seen in all age group females commencing from menarche to menopause and this disorder significantly affect the physical, sexual and emotional health and quality of life of the patients 3,4 .…”

Section: Introductionmentioning

confidence: 99%

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Assessment Clinical Association of Thyroid Function in Women of Reproductive Age Group with Abnormal Uterine Bleeding

Chaudhary¹,

Aftab²,

Iqbal³

et al. 2022

PJMHS

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Background: Abnormal Uterine Bleeding occurs when the frequency and quantity of menstrual bleeding in females is significantly altered. It is the most prevalent clinical presentation in gynecology, affecting more than 20% of the female population, and is characterized by variations from normal menstruation in terms of irregularity in periods, frequency, duration of blood flow, amount of blood loss, and cyclicity. Thyroid hormones had significant effects on the female reproductive system, such as delayed puberty, infertility, premature menopause, recurrent abortions, and AUB. The AUB is significantly associated with thyroid secretions, and any patient who complains of AUB or irregular menstruation must have thyrotoxicosis ruled out. Objectives: This study was conducted at the Department of Obstetrics and Gynecology, Nishtar Hospital, Multan, Pakistan, (2021-22) in order to evaluate the clinical association between thyroid function and AUB in women of different reproductive age groups. Methods: This cross-sectional study was conducted in the outpatient department of Obstetrics & Gynecology, Nishtar Hospital, Multan, from 1st December 2021 to 31st May 2022. 320 patients participated in the study and were examined clinic-pathologically and were allocated into three groups based on their thyroid profile (euthyroid, hyperthyroid and hypothyroid, respectively) and further predisposition risk factors were recorded and analyzed. Results: It was discovered that extreme age groups of adolescence and pre-menopause phase significantly (p<0.05) increased the incidence of AUB. The incidence of AUB was also elevated (p<0.05) among patients with an abnormal BMI, women with multiple pregnancies, and married women. The menstrual bleeding pattern was also studied in females, with polymenorrhea (131/320) being the most prevalent (p<0.05), followed by menorrhagia (79/320), metrorrhagia (59/320), oligomenorrhea (42/320), and amenorrhea (9/320) having a significantly lower incidence (p<0.05). The incidence rate of thyroid disorders was 28.12% (90/320), with hypothyroidism affecting 77(24.06%) and hyperthyroidism affecting 13(4.06%) patients (p<0.05). Practical implication: AUB is significantly associated (p<0.05) with thyroid hormones, therefore for early diagnosis of the underlying etiology and treatment of the patients by preventing hysterectomy and other serious surgical interventions, all patients presenting to OPD clinics with the complaint of AUB or irregular menstruation must be ruled out for a thyroid profile in the first instance. Conclusion: It was concluded that thyroid disorders directly affected the BMI, fertility and menstrual cycle of gynecology patients and increased the incidence of AUB along with the medical and gynecological complications. Keywords: Amenorrhea; Hyperthyroidism; Hypothyroidism; Polymenorrhea; Thyrotoxicosis.

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Section: Examination Of the Patientssupporting

confidence: 90%

supporting

confidence: 92%

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment Clinical Association of Thyroid Function in Women of Reproductive Age Group with Abnormal Uterine Bleeding

Chaudhary¹,

Aftab²,

Iqbal³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…В останні роки суттєво збільшилася частота аномальних маткових кровотеч (АМК) у жінок репродуктивного віку на тлі екстрагенітальної патології [4,5,6]. Незважаючи на значну кількість наукових досліджень з проблем АМК, питання особливостей соматичного та гінекологічного анамнезу, клінічних проявів АМК у жінок з патологією щитоподібної залози потребує більш глибокого вивчення для подальшого розроблення методів їх профілактики.…”

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Peculiarities of Somatic and Gynecological Status of Women with Abnormal Uterine Bleeding with Autoimmune Thyroiditis

Alieksieieva¹,

Лазуренко²

2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to determine the peculiarities of somatic and gynecological status of women with abnormal uterine bleeding, who have autoimmune thyroiditis. Materials and methods. 120 women of reproductive age, of whom there were 90 patients with abnormal uterine bleeding and 30 women without gynecological pathology (control group), were examined. Patients from the main group were divided into 2 clinical groups: 60 women with autoimmune thyroiditis were included in the main group and 30 women without signs of thyroid gland pathology made up the comparison group. The research was conducted and the results of anamnestic data, somatic and gynecological status, clinical laboratory and ultrasound examinations, conservative and operative treatment were analyzed. The study was conducted in the gynecological department of the Communal Non-Commercial Enterprise of the Kharkiv Regional Council “Kharkiv Regional Clinical Hospital” during 2019-2022. Statistical processing of the obtained data was performed using the “Statistica 6.0” program. Results and discussion. As a result of the analysis of the anamnesis data of the patients of the main group, a hereditary predisposition to thyroid gland diseases was revealed in the closest relatives of every fifth patient with autoimmune thyroiditis. Among the concomitant gynecological pathology, such diseases as uterine leiomyoma, endometriosis of various localization, endometrial hyperplasia were more common in patients with uterine bleeding in combination with autoimmune thyroiditis (38.3%). In addition, fibrocystic mastopathy was also observed almost twice as often in patients with abnormal uterine bleeding against the background of autoimmune thyroiditis (25%) than in the group without thyroid gland pathology, which may be due to the hormonal dependence of the above-mentioned diseases, and is a predictor of the development of hereditary endocrine dysfunction and greater susceptibility of the reproductive system to exogenous and endogenous factors. When studying the somatic status of patients with abnormal uterine bleeding in combination with autoimmune thyroiditis, a significant prevalence of comorbid somatic pathology was noted. Among women with 2-3 concomitant diseases, the following combinations were most common: hypertension and obesity (13%); hypertension, chronic pancreatitis, varicose veins of the lower extremities (7%), chronic pyelonephritis, fibrocystic mastopathy. Every third patient had a combination of obesity, liver disease, and hypertension. It should be noted that in women with abnormal uterine bleeding without autoimmune thyroiditis, the accompanying pathology was twice as low as in the group suffering from the specified thyroid disease. Menstrual cycle disorders of various nature were detected. Irregular menstrual cycle occurred twice as often in women with abnormal uterine bleeding against the background of autoimmune thyroiditis than in women without concomitant thyroid disease – in 8 (13.3%) and 2 (6.7%) women, respectively. The analysis of the peculiarities of the generative function allowed to reveal a statistically significant predominance of women with primary infertility (13.3%). Secondary infertility occurred almost twice as often and was diagnosed in 20% of women. Almost every third woman with abnormal uterine bleeding and autoimmune thyroiditis had a history of reproductive loss (35%). In 16.7% of patients, habitual miscarriage was revealed. 3.33% had a history of ectopic pregnancy. Conclusion. The analysis of somatic diseases in women with autoimmune thyroiditis demonstrates their influence on the development of gynecological pathology, especially menstrual cycle disorders, in particular abnormal uterine bleeding, which requires the search for new approaches to their treatment and prevention

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A cross sectional study to evaluate the relation between thyroid disorders and abnormal uterine bleeding in reproductive age group

Cited by 2 publications

References 8 publications

Assessment Clinical Association of Thyroid Function in Women of Reproductive Age Group with Abnormal Uterine Bleeding

Assessment Clinical Association of Thyroid Function in Women of Reproductive Age Group with Abnormal Uterine Bleeding

Peculiarities of Somatic and Gynecological Status of Women with Abnormal Uterine Bleeding with Autoimmune Thyroiditis

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