A Cross Sectional Study to Observe Adherence to Antihypertensive Treatment and Associated Factors among Hypertensive Patient on Follow Up in Debre Berhan Referral Hospital, North Shoa, Ethiopia, 2017

Adherence to antihypertensive medications and associated factors among hypertensive patients in Ethiopia: Systematic review and meta-analysis

“…The full-text papers of 31 articles were retrieved and reviewed for inclusion which resulted in a total of 18 studies eligible for the methodological quality assessment. After excluding four studies with reasons mainly a weak quality score, 14 studies were included in the final SR (qualitative synthesis) [19][20][21][22][23][24][25][26][27][28][29][30][31][32] and 12 of them were also included in MA ( Figure 1).…”

“…The sample size of studies was ranged from 100 24 to 1600 28 subjects, and the total sample sizes included for this review were 4938. Systematic random sampling was the main sampling technique which was used by six studies, 20,26,[28][29][30]32 , while six studies were included all adult hypertensive patients visiting the chronic follow-up clinic during data collection. 19,21,22,24,25,27 Face-to-face interviews with chart review were the main data collection technique used by eight studies 19 -21,23,25,26,28,30 while five studies 22,24,29,31,32 used interview (non-specific) technique and only one study 27 used self-administered questionnaires to assess adherence.…”

“…Methods of assessing adherence. The aim of eight studies was to assess the magnitude of adherence to antihypertensive medication and associated factors among hypertensive patie nts, 20,21,25,26,[29][30][31][32] while three studies were aimed to assess the proportion of non-adherence to antihypertensive medication and associated factors among hypertensive patients, 19,23,24 one study 22 was aimed to assess the patient compliance and associated factors of antihypertensive treatments, another study 28 was designed to assess the determinants of adherence to antihypertensive medication, and the remaining study 27 was intended to measure the contribution of adverse effects on antihypertensive medications adherence.…”

“…32 Except for a study in Jimma, 25 which showed a statistically significant association between marital status and medication adherence (p-value < 0.05), no study in Ethiopia shown an association between antihypertensive medication adherence and occupational or marital status of the patients. 19,20,23,26,29,30,32 Disease/condition-related factors. Nine studies found significant associations between disease-related factors like comorbidities, complication, stage of hypertension, BP controlled, having symptoms (muscle pain, tiredness, poor sleep) and forget the fullness of their drugs to adherence with antihypertensive medication [19][20][21][26][27][28][29][30][31] (Table 4).…”

“…19 The Debre Berhan study also revealed that hypertensive patients with comorbid heart disease were 95.7% less likely (AOR = 0.043, 95% CI: 0.03-0.7) to adhere to their antihypertensive treatment than patients without comorbid heart disease. 26 However, a study in Debre Tabor indicated that having comorbidities like diabetes, cardiovascular disease (CVD), or asthma had no association with medication adherence. 31 The study in northern Ethiopia 19 found that patients at the pre-hypertension level (BP between 120/80 and 140/90 mm Hg) were 94.8% less likely (AOR = 0.052, 95% CI: 0.003-0.242) to be adherent to their medications than patients with higher BP (>160/100 mm Hg).…”