A cross-sectional study to correlate antioxidant enzymes, oxidative stress and inflammation with prevalence of hypertension

Kaur, Sukhchain; Rubal,; Kaur, Simranjit; Kaur, Amandeep; Kaur, Sandeep; Gupta, Sushil K.; Mittal, Sunil; Dhiman, Monisha

doi:10.1016/j.lfs.2022.121134

Cited by 10 publications

(2 citation statements)

References 99 publications

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“…Based on the integrated network, 9 Q-markers may regulate phosphatidylinositol-3-kinase/Akt (PI3K-Akt), FoxO, tumor necrosis factor (TNF), mitogen-activated protein kinase (MAPK), HIF-1, vascular endothelial growth factor (VEGF) and other signaling pathways through acting on AKT1, TNF, EGFR, JUN, STAT3, SRC, CASP3, MAPK3, HSP90AA1 and HIF1A targets to achieve the protective effect on the liver. Oxidative stress has been closely associated with almost all human liver diseases (Kaur et al, 2022). The related research has reported that the FoxO signaling pathway is involved in oxidative stress-induced apoptosis and plays a significant role in regulating the cellular oxidative stress response.…”

Section: Discussionmentioning

confidence: 99%

A funnel-type stepwise filtering strategy for identification of potential Q-markers of traditional Chinese medicine formulas

et al. 2023

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Quality marker (Q-marker) serves as an important driver for the standardization of quality control in traditional Chinese medicine (TCM) formulas. However, it is still challenging to discover comprehensive and representative Q-markers. This study aimed to identify Q-markers of Hugan tablet (HGT), a famous TCM formula with ideal clinical effects in liver diseases. Here, we proposed a funnel-type stepwise filtering strategy that integrated secondary metabolites characterization, characteristic chromatogram, quantitative analysis, literature mining, biotransformation rules and network analysis. Firstly, the strategy of “secondary metabolites-botanical drugs-TCM formula” was applied to comprehensively identify the secondary metabolites of HGT. Then, the secondary metabolites with specificity and measurability in each botanical drug were identified by HPLC characteristic chromatogram, biosynthesis pathway and quantitative analysis. Based on literature mining, the effectiveness of botanical metabolites that met the above conditions was evaluated. Furthermore, the metabolism of the above metabolites in vivo was studied to reveal their biotransformation forms, which were used for network analysis. At last, according to biotransformation rules of the prototype drugs in vivo, the secondary metabolites were traced and preliminarily chosen as Q-markers. As a result, 128 plant secondary metabolites were identified in HGT, and 11 specific plant secondary metabolites were screened out. Then, the content of specific plant secondary metabolites in 15 batches of HGT was determined, which confirmed their measurability. And the results of literature mining showed that eight secondary metabolites had therapeutic effects in treating liver disease at the in vivo level, and three secondary metabolites inhibited liver disease-related indicators at the in vitro level. After that, 26 compounds absorbed into the blood (11 specific plant metabolites and their 15 metabolites in vivo) were detected in rats. Moreover, 14 compounds, including prototype components and their metabolites, were selected as Q-marker candidates by the “TCM formula-botanical drugs-compounds-targets-pathways” network. Finally, 9 plant secondary metabolites were defined as comprehensive and representative Q-markers. Our study not only provides a scientific basis for the improvement and secondary development of the quality standard of HGT, but also proposes a reference method for discovering and identifying Q-markers of TCM preparations.

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Section: Discussionmentioning

confidence: 99%

A funnel-type stepwise filtering strategy for identification of potential Q-markers of traditional Chinese medicine formulas

et al. 2023

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“…Most of these tested biomarkers are related to a systemic inflammatory process, and this is not surprising, since it is known that a systemic inflammation can be associated with cancer development and progression [20,[26][27][28][29]. CRP is the only single biomarker that, according to the literature, is prognostic of both bone and soft tissue sarcomas as well as for cancer [15,20,[30][31][32][33]. Avnet et al reported that tumor acidosis could be directly associated with tumor invasion [26].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of the Serum Level of C-Reactive Protein for Survival of Children with Ewing’s Sarcoma

Errani

Traversari

Cosentino

et al. 2023

Cancers

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The purpose of the present study was to evaluate the prognostic role of C-reactive protein (CRP) in children with Ewing’s sarcoma. We conducted a retrospective study on 151 children undergoing multimodal treatment for Ewing’s sarcoma in the appendicular skeleton from December 1997 to June 2020. Univariate Kaplan-Meier analyses of laboratory biomarkers and clinical parameters showed that CRP and metastatic disease at presentation were poor prognostic factors associated with overall survival and disease recurrence at 5 years (p < 0.05). A multivariate Cox regression model showed that pathological CRP (≥1.0 mg/dL) [HR of 3.67; 95% CI, 1.46 to 10.42] and metastatic disease [HR of 4.27; 95% CI, 1.58 to 11.47] were associated with a higher risk of death at 5 years (p < 0.05). In addition, pathological CRP (≥1.0 mg/dL) [HR of 2.66; 95% CI, 1.23 to 6.01] and metastatic disease [HR of 2.56; 95% CI, 1.13 to 5.55] were associated with a higher risk of disease recurrence at 5 years (p < 0.05). Our findings demonstrated that CRP was associated with the prognosis of children with Ewing’s sarcoma. We recommend pre-treatment measurement of the CRP in order to recognize children with Ewing’s sarcoma who are at greater risk of death or local recurrence.

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Separation and purification of antioxidant peptides from Idesia polycarpa Maxim. cake meal and study of conformational relationship between them

Dou,

Zhang,

Yang

et al. 2024

Food Science & Nutrition

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In this study, peptides were isolated and purified from Idesia polycarpa Maxim. cake meal for the first time, with the aim of discovering peptides with excellent antioxidant properties. Peptides were isolated and purified from the cake meal using ultrafiltration and dextran gel chromatography. Fractions with significant antioxidant activity were identified by mass spectrometry (MS) and the peptides were screened and characterized using techniques, such as network pharmacology and molecular docking. The results showed that the CIPs‐I‐F2 fractions possessed excellent antioxidant activities, and a total of seven peptides were screened, with the main targets of action including serine/threonine‐protein kinase AKT (AKT1), signal transducer and activator of transcription 3 (STAT3), and matrix metalloproteinase 9 (MMP9), among which ISKPTWADF had the highest total binding energy to the target. ISKPTWADF was synthesized in vitro by solid‐phase synthesis and showed a dose‐dependent protective effect against the hydrogen peroxide (H2O2)‐induced oxidative damage model in human hepatocellular carcinoma HepG2 cells, with its main active site on the tryptophan indole ring at position 52N‐127H.

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A cross-sectional study to correlate antioxidant enzymes, oxidative stress and inflammation with prevalence of hypertension

Cited by 10 publications

References 99 publications

A funnel-type stepwise filtering strategy for identification of potential Q-markers of traditional Chinese medicine formulas

A funnel-type stepwise filtering strategy for identification of potential Q-markers of traditional Chinese medicine formulas

The Prognostic Value of the Serum Level of C-Reactive Protein for Survival of Children with Ewing’s Sarcoma

Separation and purification of antioxidant peptides from Idesia polycarpa Maxim. cake meal and study of conformational relationship between them

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