A cross-sectional survey based on blood VOCs, hematological parameters and urine indicators in a population in Jilin, Northeast China

Li, Xiaocui; Guo, Yuanyuan; Song, Xiaofeng; He, Yinghua; Zhang, Huiwen; Xu, Gang; Li, Xinxin; Liu, Yu‐Shen; Zhai, Yue; Wang, Juan; Xu, Kun; Li, Juan

doi:10.1007/s10653-019-00241-6

Cited by 5 publications

(5 citation statements)

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“…However, other researchers disagree with these results and a study of 74.828 benzene exposed workers did not find a sex-related higher incidence of leukemia and hematopoietic and lymphoproliferative disorders [ 65 ]. Low-dose exposure brought no significant difference in blood benzene concentrations between sexes [ 64 ], while changes were observed in the urinary leukocyte count, more significant in females than males. The higher values of benzene in women were linked to increased urinary white blood cells by 2.902%.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding evidence in humans, sex-specific divergences seem to be a parameter of interest considering benzene exposure and its health effects. The published findings showed a possibility of greater risks of specific health effects for women, such as leukemia, although with some uncertainties [ 64 ], epidemiological evidence shows the greater involvement of women in adverse effects related to exposure to benzene, especially considering the hematochemical profile [ 62 ], while regarding other possible effects, like genotoxic effects, weak association emerged [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, no statistical differences (p > 0.05) between sexes were found in genotoxic biomarkers (micronuclei assay, comet test). Erythrocytes, hemoglobin and hematocrit percentage were higher in male-exposed workers than females (p < 0.05), while platelets were decreased in exposed men than women Li et al 2019 [64] Cross-sectional…”

Section: Sex Difference and Benzene Exposure: Findings In Humansmentioning

confidence: 97%

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Sex Difference and Benzene Exposure: Does It Matter?

Poli

Mozzoni

Pinelli

et al. 2022

IJERPH

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Sex-related biological differences might lead to different effects in women and men when they are exposed to risk factors. A scoping review was carried out to understand if sex could be a discriminant in health outcomes due to benzene. Studies on both animals and humans were collected. In vivo surveys, focusing on genotoxicity, hematotoxicity and effects on metabolism suggested a higher involvement of male animals (mice or rats) in adverse health effects. Conversely, the studies on humans, focused on the alteration of blood parameters, myeloid leukemia incidence and biomarker rates, highlighted that, overall, women had significantly higher risk for blood system effects and a metabolization of benzene 23–26% higher than men, considering a similar exposure situation. This opposite trend highlights that the extrapolation of in vivo findings to human risk assessment should be taken with caution. However, it is clear that sex is a physiological parameter to consider in benzene exposure and its health effects. The topic of sex difference linked to benzene in human exposure needs further research, with more numerous samples, to obtain a higher strength of data and more indicative findings. Sex factor, and gender, could have significant impacts on occupational exposures and their health effects, even if there are still uncertainties and gaps that need to be filled.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Sex Difference and Benzene Exposure: Findings In Humansmentioning

confidence: 97%

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Sex Difference and Benzene Exposure: Does It Matter?

Poli

Mozzoni

Pinelli

et al. 2022

IJERPH

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“…Finally, there was a significant negative correlation between MCHC and PLT counts and a positive correlation between monocyte counts with blood benzene levels. Another cross-sectional study was conducted by Li et al in Jilin, China [73]. They selected 499 adults not occupationally exposed to industrial emissions who lived for more than 5 years in the residential area of the Jilin Petrochemical Industrial Park.…”

Section: Hematological Sidementioning

confidence: 99%

Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas

Cordiano

Papa

Cicero

et al. 2022

Toxics

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Literature is teeming with publications on industrial pollution. Over the decades, the main industrial pollutants and their effects on human health have been widely framed. Among the various compounds involved, benzene plays a leading role in the onset of specific diseases. Two systems are mainly affected by the adverse health effects of benzene exposure, both acute and chronic: the respiratory and hematopoietic systems. The most suitable population targets for a proper damage assessment on these systems are oil refinery workers and residents near refining plants. Our work fits into this area of interest with the aim of reviewing the most relevant cases published in the literature related to the impairment of the aforementioned systems following benzene exposure. We perform an initial debate between the two clinical branches that see a high epidemiological expression in this slice of the population examined: residents near petroleum refinery areas worldwide. In addition, the discussion expands on highlighting the main immunological implications of benzene exposure, finding a common pathophysiological denominator in inflammation, oxidative stress, and DNA damage, thus helping to set the basis for an increasingly detailed characterization aimed at identifying common molecular patterns between the two clinical fields discussed.

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“…A study observed that cancer incidence, including stomach, bronchus, lung, and prostate, increased among persons living near a municipal solid waste landfill site that generated many VOCs (15). Although most research used empirical data in the environmental distribution and risk analysis, personal laboratory data was considered the best similar to actual exposure (16,17). The limitations of the association between the blood VOCs concentration and parameters of liver, kidney, hematologic, endocrine and prostate functions still exist, especially in the average population (18).…”

Section: Introductionmentioning

confidence: 99%

Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001–2010

Wei

Chen

Yang

et al. 2022

Front. Public Health

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BackgroundVolatile organic compounds (VOCs) are a large group of chemicals widely used in people's daily routines. Increasing evidence revealed the VOCs' accumulating toxicity. However, the VOCs toxicity in male prostate has not been reported previously. Thus, we comprehensively evaluated the association between VOCs and prostate-specific antigen (PSA).MethodsA total of 2016 subjects were included in our study from the National Health and Nutrition Examination Survey with VOCs, PSA, and other variables among U.S. average population. We constructed XGBoost Algorithm Model, Regression Model, and Generalized linear Model (GAM) to analyze the potential association. Stratified analysis was used to identify high-risk populations.ResultsXGBoost Algorithm model identified blood chloroform as the most critical variable in the PSA concentration. Regression analysis suggested that blood chloroform was a positive association with PSA, which showed that environmental chloroform exposure is an independent risk factor that may cause prostate gland changes [β, (95% CI), P = 0.007, (0.003, 0.011), 0.00019]. GAM observed the linear relationship between blood chloroform and PSA concentration. Meanwhile, blood chloroform linear correlated with water chloroform in the lower dose range, indicating that the absorption of water may be the primary origin of chloroform. Stratified associations analysis identified the high-risk group on the chloroform exposures.ConclusionThis study revealed that blood chloroform was positively and independently associated with total PSA level, suggesting that long-term environmental chloroform exposure may cause changes in the prostate gland.

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A cross-sectional survey based on blood VOCs, hematological parameters and urine indicators in a population in Jilin, Northeast China

Cited by 5 publications

References 41 publications

Sex Difference and Benzene Exposure: Does It Matter?

Sex Difference and Benzene Exposure: Does It Matter?

Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas

Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001–2010

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