A current view of molecular dissection in autophagy machinery

Al-Bari, Abdul Alim

doi:10.1007/s13105-020-00746-0

Cited by 33 publications

(20 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From a mechanical point of view, the autophagic process can be divided into seven main stages, as depicted in Figure 1: initiation, nucleation, elongation, closure, autophagosome maturation and transportation toward the perinuclear region of the cell, fusion with the lysosome, and finally, cargo degradation and recycling (25).…”

Section: Step-by-step Mechanics Of Autophagymentioning

confidence: 99%

“…Hence, this stage follows the same dynamics with lipid being recruited through ATG9-mediated fusion and/or transfer (Figure 1elongation; membrane recruitment) and polymerization of actin cytoskeleton to structurally support the growing double membrane and maintain its shape (67) (Figure 1-elongation; actin polymerization). These processes are under strict regulation by several ATG proteins (such as ATG3, ATG7, ATG5, ATG12 and ATG16L1), including the lipidated LC3/GABARAP protein family (25). The lipidation process occurs by conjugating the cytosolic LC3-I protein to phosphatidylethanolamine (PE), which generates the membrane bound LC3-II (68)(69)(70).…”

Section: Elongation and Closure Stagesmentioning

confidence: 99%

See 1 more Smart Citation

Mechanobiology of Autophagy: The Unexplored Side of Cancer

et al. 2021

View full text Add to dashboard Cite

Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses. Cancer transformation is a common negative consequence of mismanagement of coordinated response by the cell. In this scenario, by maintaining the balance among synthesis, degradation, and recycling of cytosolic components including proteins, lipids, and organelles the process of autophagy plays a central role. Several environmental stresses activate autophagy, among those hypoxia, DNA damage, inflammation, and metabolic challenges such as starvation. In addition to these chemical challenges, there is a requirement for cells to cope with mechanical stresses stemming from their microenvironment. Cells accomplish this task by activating an intrinsic mechanical response mediated by cytoskeleton active processes and through mechanosensitive protein complexes which interface the cells with their mechano-environment. Despite autophagy and cell mechanics being known to play crucial transforming roles during oncogenesis and malignant progression their interplay is largely overlooked. In this review, we highlight the role of physical forces in autophagy regulation and their potential implications in both physiological as well as pathological conditions. By taking a mechanical perspective, we wish to stimulate novel questions to further the investigation of the mechanical requirements of autophagy and appreciate the extent to which mechanical signals affect this process.

show abstract

Section: Step-by-step Mechanics Of Autophagymentioning

confidence: 99%

Section: Elongation and Closure Stagesmentioning

confidence: 99%

Mechanobiology of Autophagy: The Unexplored Side of Cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved, cellular homeostatic process that facilitates nutrient recycling via lysosomal degradation of potentially harmful cytoplasmic entities 21,22 . It has been widely established that the bipolar nature of autophagy exists in cancers 23,24 .…”

Section: Role Of Bulk Autophagy In Cancermentioning

confidence: 99%

Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics

Al-Bari

2020

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

Cancer becomes the principal originator of morbidity and mortality rates in the next few years in both developed and transitioning economy countries. 1-3 The scientific society has given enormous struggles and endeavour to advance innovative strategies for cancer therapy to deal efficiently with this uprising and complicating issue. Although the advanced cancer therapies are progressing from the survival rate of patients, cancer still persists one of the most fatal epidemic maladies. Cancer recurrence and metastatic progression are frequent in patients receiving conventional chemotherapy or radiotherapy. 4 As contemporary chemotherapeutics are most efficient

show abstract

“…Autophagosomes fuse directly with lysosomes, or fuse with endosomes first, and transport to lysosomes afterwards to form autophagic lysosomes. (2,(62)(63)(64) In recent years, the research of autophagy in various diseases has been deepened gradually, such as psychiatric diseases, cutaneous melanoma, and so on. (65,66) Simultaneously, autophagy plays an important role in the pathogenesis and progression of endometriosis.…”

Section: Autophagymentioning

confidence: 99%

cGAS-STING pathway participates in endometriosis by up-regulating autophagy:Review.

zhu¹,

Chen²,

Du³

et al. 2020

Preprint

View full text Add to dashboard Cite

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthetase (cGAS) and its downstream interferon gene stimulator (STING) act as important immune monitoring media have become a research hotspot. cGAS-STING pathway may play a key role in the occurrence and development of endometriosis by regulating autophagy. The combination of inhibitors targeting cGAS-STING with estrogen or surgery may become a therapeutic approach for endometriosis, and we present a review about the mechanism and physiological function of cGAS-STING pathway, typical autophagy and STING-dependent atypical autophagy, autophagy expression in endometriosis, and a new idea that cGAS-STING may be involved in endometriosis by regulating autophagy.

show abstract

A current view of molecular dissection in autophagy machinery

Cited by 33 publications

References 97 publications

Mechanobiology of Autophagy: The Unexplored Side of Cancer

Mechanobiology of Autophagy: The Unexplored Side of Cancer

Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics

cGAS-STING pathway participates in endometriosis by up-regulating autophagy:Review.

Contact Info

Product

Resources

About