A curvilinear isogeometric framework for the electromechanical activation of thin muscular tissues

Nitti, Alessandro; Kiendl, Josef; Gizzi, Alessio; Reali, Alessandro; Tullio, Marco D. de

doi:10.1016/j.cma.2021.113877

Cited by 17 publications

(2 citation statements)

References 57 publications

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“…This work only considers cardiac electrophysiological simulations, neglecting tissue contraction. Mechanics could also be included, as shown in [20], further improving the realism of the simulation. Indeed, the in-vitro setup also investigates the intraventricular pressure-volume loops using catheter-based systems to assess the effect of compounds on tissue contractility.…”

Section: Spatial Discretizationmentioning

confidence: 99%

Isogeometric simulation of a derived stem cell engineered ventricle

Botti,

Torre

2023

ACSE

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Regenerative cardiology recently advanced in patient-specific medicine by employing somatic cells to derive pluripotent stem cells and differentiate them into cardiomyocytes.In this work, the cardiac Monodomain model is coupled with stem cell ionic models to simulate the action potential propagation in the engineered ventricle. The cardiac model is then discretized by means of Isogeometric Analysis, carrying out numerical experiments to assess the accuracy of the approach. Finally, the presented framework is used to investigate the propagation of an action potential on the calibrated model of the engineered ventricle.

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Section: Spatial Discretizationmentioning

confidence: 99%

Isogeometric simulation of a derived stem cell engineered ventricle

Botti,

Torre

2023

ACSE

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“…16 Moreover, we also discuss the IGA in the context of transient diffusion problems where previously only steady-state problems were discussed. Although the presented work focuses on heat conduction within the thermo-mechanical context but the work here is also very relevant to other applications including for example the growth-phenomena 22,23 and electro-mechanics 24,25 where the diffusion also needs to be solved. Major motivation for this analysis is its application in a future work to forecast thermal stresses in plates due to heat conduction.…”

Section: Introductionmentioning

confidence: 99%

High-order methods for thermal behavior of plate structures with internal heat sources

Bouna

Izem

Seaı̈d

et al. 2022

Proceedings of the Institution of Mechanical Engineers, Part C:

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The paper proposes solving transient heat transfer in plates using high-order isogeometric analysis and high-order time integration schemes. The problem is often faced in fire-structure interaction where the heat transfer is coupled with the stress analysis. A major advantage for the proposed approach comes from high order continuity between elements. Thus, the need for rotational degrees of freedom is eliminated when analyzing the stresses in plates and the same mesh can also be used to recover the heat transfer patterns. To achieve the full potential of such high-order finite elements in space, we also use high-order time integration schemes so that the numerical solution can be significantly more accurate than the standard approaches. Furthermore, the isogeometric analysis is also used to represent the exact geometry thanks to the basis functions generated from Non-Uniform Rational B-Splines. Several test examples for the transient diffusion problem are presented. Compared to standard methods and for a prescribed accuracy the proposed approach requires significantly fewer degrees of freedom and a corresponding improvement in the computational efficiency.

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