A Cyclometallated Platinum Complex as a Selective Optical Switch for Quadruplex DNA

Abstract

Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.

Organometallic Complexes as Enzyme Inhibitors: A Conceptual Overview

“…Diverse types of compounds were encapsulated into the organometallic cages including photosensitizers [135], antiproliferative agents [136,137], fluorescent agents [138,139], dendrimers [140,141], and recently enzyme inhibitors [142,143]. For the latter, two different kinds of enzyme inhibitors were encapsulated into the organometallic cages, namely: (1) synthetic nucleoside derivatives such as the FDA-approved anticancer drug used against colorectal cancer Floxuridine, which is an irreversible inhibitor of thymidylate synthase and (2) antiproliferative ruthenium arene complexes from the so-called RAPTA family (see Figure 1 for the chemical structures of these compounds).…”

Discrete Metalla‐Assemblies as Drug Delivery Vectors

“…Other platinum complexes have been encapsulated in the cationic [{(pPr i C 6 H 4 Me)Ru} 6 (donq) 3 (tpt) 2 ] 6+ metalla-prism, {2-(pyridin-l-yl) pyridine}Pt(acac) (a), (2-(4-(pyridin-l-yl)phenyl)pyridine}Pt(acac) (b) [22] and {2-phenyl-6-(2-(piperidin-l-yl)ethoxy)-l,10-phenanthroline)PtCl (c) [23] (Figure 4.3). These square-planar complexes are clearly hydrophobic with these large planar aromatic surfaces, and would have been unable to enter cells without help.…”

“…Platinum complexes for encapsulation in the water-soluble metallaprism [((pPr i C 6 H 4 Me)Ru| 6 (donq) 3 (tpt) 2 ] 6+ , (2-(pyridin-l-yl)pyridine)Pt(acac) (a), {2-(4-(pyridin-l-yl)phenyl)pyridine|Pt(acac); (b)[22] and |2-phenyl-6-(2-(piperidin-l-yl)ethoxy)-l,iO-phenanthroline|PtCl (c)[23].…”

“…Fluorescence images of [Cc((pPr'C 6 H 4 Me)Ru) 6 -(donq) 3 (tpt) 2 ] 6+ on U20S cells, DAPI staining of the nucleus (left), red fluorescence due to C (middle), and overlap of the two images (right)[23].…”

A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

“…and Ccoordinated phenylpyridine ligands, 12 have exhibited considerably stronger interactions with G-quadruplex DNA for possessing an extended p-surface. Though a few small molecules have been studied to specically bind multimeric G-quadruplex structures, 13-18 most square-planar Pt(II) phenanthroline complexes have been discussed to selectively bind monomeric G-quadruplexes rather than multimeric Gquadruplexes.…”