This work was conducted to determine the prevalence of E. coli, cryptosporidium spp., giardia, rotavirus and coronavirus agents involved in the etiology of diarrhea in cases of neonatal calf diarrhea detected in Burdur Mehmet Akif Ersoy University Animal Hospital Clinics and other farms in the region between 2019-2020 years. The material of the study consisted of 50 neonatal calves with diarrhea. Stool samples were taken from calves with diarrhea and examined with immunochromatographic rapid test kits. One or more enteropathogenic agents were detected in 70% of the calves. In calves with diarrhea, Cryptosporidium spp (42%) and rotavirus (30%) were detected as single and mixed enteropathogen. Mixed enteropathogens (14% Cryptosporidium spp. + Rotavirus, 2% Rotavirus + coronavirus, 2% Cryptosporidium spp. + rotavirus + coronavirus + E. coli K99 + Giardia, 2% Cryptosporidium spp. + coronavirus + E. coli K99 + Giardia) were determined in 20% of calves. As a result, it was concluded that in neonatal calf diarrhea, cryptosporidium and rotavirus factors are common and necessary precautions should be taken in enterprises against these factors.