2019
DOI: 10.26434/chemrxiv.11110133.v1
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A Cysteine Selenosulfide Redox Switch for Protein Chemical Synthesis

Abstract: <div>We describe a cyclic selenosulfide derivative of cysteine called SetCys that enables to perform protein chemical synthesis under redox-control.</div><div>Native chemical ligation or SEA-mediated ligation with SetCys peptide segments proceeds in a traceless manner and involves the cleavage of a carbon-nitrogen bond in situ.</div><div>The manuscript describes detailed mechanistic investigations of SetCys redox-switch and its application to the production of biologically active … Show more

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