2023
DOI: 10.1101/2023.08.28.555220
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A defined diet for pre-adultDrosophila melanogaster

Felipe Martelli,
Annelise Quig,
Sarah Mele
et al.

Abstract: Drosophilamelanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and survival. Here, we provide an adjusted formula that improves larval growth, development rate, and rescues survival. We demonstrate its use for exploring pre-adult diet compositions of therapeutic potential in a model of an inherited metabolic disorder.

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Cited by 2 publications
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“…To reveal fly AAD models with phenotypes modifiable by diet, we devised a two-diet screen using both a standard SY fly medium and a recently devised synthetic complete medium that fully supports the preadult period 15 , 56 ( Figure 1A ). The SY medium is widely used in Drosophila research and is based on natural ingredients, sugar, and yeast ( Table S2 ).…”
Section: Resultsmentioning
confidence: 99%
“…To reveal fly AAD models with phenotypes modifiable by diet, we devised a two-diet screen using both a standard SY fly medium and a recently devised synthetic complete medium that fully supports the preadult period 15 , 56 ( Figure 1A ). The SY medium is widely used in Drosophila research and is based on natural ingredients, sugar, and yeast ( Table S2 ).…”
Section: Resultsmentioning
confidence: 99%