A dependency model for patients with Alzheimer's disease: its validation and relationship to the costs of care – the LASER-AD Study

Livingston, Gill; Katona, Cornelius; Roch, Brigitte; Guilhaume, C; Rive, B.

doi:10.1185/030079904125003980

Cited by 50 publications

(48 citation statements)

References 19 publications

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“…Livingston and colleagues (LASER-AD Study) 146 report findings from a UK epidemiological study of 224 AD patients. The objective of this study was to validate a functional classification model of AD patients, exploring the relationship between dependency and costs of care.…”

Section: Stewartmentioning

confidence: 99%

“…Data for these cost estimates are not presented in any detail, with the authors citing the LASER-AD Study 146 as the source for resource use calculations. These costs are much higher than other published cost data for AD, especially for severe AD [see the section 'Costing considerations in the treatment of AD' (p. 108)].…”

Section: Estimation Of Costsmentioning

confidence: 99%

“…Transit probabilities by dependency are cited from the LASER-AD Study 146 and the RCT from Reisberg and colleagues. 72 These probabilities are reported in the industry submission but do not form part of the published papers.…”

Section: Comments On Industry Submission For Memantinementioning

confidence: 99%

“…The source for the mortality data used in the model is cited as the LASER-AD Study 146 but the data used are not reported in the published paper; 6-monthly rates of 3.1, 7.1 and 18.8% are used in the model for mild-moderate, moderate-severe and severe AD, respectively.…”

Section: Comments On Industry Submission For Memantinementioning

confidence: 99%

“…In the UK study by Jones and colleagues, the initial distribution of patients by severity, dependency and institutionalisation was based on a UK epidemiological study -the LASER AD Study 146 [see the section 'Costing considerations in the treatment of AD' (p. 108) for an outline summary 72 and data from the LASER-AD Study. Transit probabilities for dependency and location were based on a transformation of the rates from the no pharmacological treatment group using an estimated OR for memantine versus placebo, using clinical trial data.…”

Section: François and Colleagues'/jones And Colleagues' Model Of Ad Pmentioning

confidence: 99%

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Section: Stewartmentioning

confidence: 99%

Section: Estimation Of Costsmentioning

confidence: 99%