A descending pathway emanating from the periaqueductal gray mediates the development of cough-like hypersensitivity

Chen, Zhe; Lin, Ming-Tong; Zhan, Cheng; Zhong, Nanshan; Mu, Di; Lai, Kefang; Liu, Mingzhe

doi:10.1016/j.isci.2021.103641

Cited by 12 publications

(4 citation statements)

References 53 publications

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“…These processes are expected to contribute to cough hypersensitivity via amplifying inputs from cough sensory fibres. Consistent with this, upregulated cough network activity in the midbrain has been demonstrated in patients with cough hypersensitivity 101 , in regions reportedly involved in the development of other sensory hypersensitivities 102 , 103 .…”

Section: Mechanisms/pathophysiologysupporting

confidence: 67%

Cough hypersensitivity and chronic cough

Chung

McGarvey

Song

et al. 2022

Nat Rev Dis Primers

160

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Chronic cough is globally prevalent across all age groups. This disorder is challenging to treat because many pulmonary and extrapulmonary conditions can present with chronic cough, and cough can also be present without any identifiable underlying cause or be refractory to therapies that improve associated conditions. Most patients with chronic cough have cough hypersensitivity, which is characterized by increased neural responsivity to a range of stimuli that affect the airways and lungs, and other tissues innervated by common nerve supplies. Cough hypersensitivity presents as excessive coughing often in response to relatively innocuous stimuli, causing significant psychophysical morbidity and affecting patients’ quality of life. Understanding of the mechanisms that contribute to cough hypersensitivity and excessive coughing in different patient populations and across the lifespan is advancing and has contributed to the development of new therapies for chronic cough in adults. Owing to differences in the pathology, the organs involved and individual patient factors, treatment of chronic cough is progressing towards a personalized approach, and, in the future, novel ways to endotype patients with cough may prove valuable in management.

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Section: Mechanisms/pathophysiologysupporting

confidence: 67%

Cough hypersensitivity and chronic cough

Chung

McGarvey

Song

et al. 2022

Nat Rev Dis Primers

160

View full text Add to dashboard Cite

show abstract

“…These processes are expected to amplify the inputs from cough sensory fibres and contribute to the development of cough hypersensitivity. Consistent with this, upregulated cough network activity in the mid-brain has been demonstrated in patients with cough hypersensitivity 104 , in regions reportedly involved in the development of other sensory hypersensitivities 105,106 .…”

Section: [H2] Central Mechanisms Regulating Cough Sensitivitysupporting

confidence: 67%

Cough hypersensitivity and chronic cough

2022

Nat Rev Dis Primers

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“…The asthma attack is closely related to emotional disorder ( 24 , 25 ), which involves higher brain regions ( 26 ), and specific brain networks and brain regions are more active ( 27 , 28 ). The nucleus in the brainstem is a key site that regulates respiratory control ( 29 , 30 ), such as cough ( 31 ), and vagal nerves have been shown to be involved in modulation of the afferent signal ( 32 , 33 ). Therefore, we speculate that GDNF is a key mediator in both the CNS and peripheral nervous system during asthma.…”

Section: Discussionmentioning

confidence: 99%

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats

Wang¹,

Wang²,

Chen³

et al. 2023

Ann Transl Med

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Background Asthma is a common chronic inflammatory disease of the airway, but the mechanism is still not fully understood. This study aimed to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on asthma attacks. Methods An asthmatic rat model was established. GDNF expression in the airway and brain was observed by immunohistochemistry (IHC), and the concentration of GDNF in bronchoalveolar lavage fluid (BALF) was detected by enzyme-linked immunosorbent assay (ELISA). After injection of GDNF and its antibody into the lateral ventricle of asthmatic rats, the pulmonary function was recorded, and the levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in BALF were tested. Results GDNF expressions were increased significantly in the lung tissues of asthmatic rats. In the central nervous system (CNS), GDNF-positive immunoreactive substances were observed in multiple brain regions, including the medial amygdala (MeA), paraventricular nucleus (PVN), cortex, and nucleus of solitary tract (NTS). After injection of GDNF into the lateral ventricles of asthmatic rats, the symptoms of asthma and airway inflammation were significantly aggravated, which could be improved by injection of GDNF antibody into the lateral ventricles. Conclusions GDNF expression is increased in the lung and brain in asthmatic rats. During an asthma attack, the increased GDNF expressions in the rat brain remarkably aggravate the asthmatic symptoms.

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A descending pathway emanating from the periaqueductal gray mediates the development of cough-like hypersensitivity

Cited by 12 publications

References 53 publications

Cough hypersensitivity and chronic cough

Cough hypersensitivity and chronic cough

Cough hypersensitivity and chronic cough

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats

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