A description of genes of Corynebacterium pseudotuberculosis useful in diagnostics and vaccine applications

Abstract

ABSTRACT. Corynebacterium pseudotuberculosis, a Gram-positive intracellular pathogen, is the etiological agent of caseous lymphadenitis or CLA. This bacterium infects goats and sheep and causes great economic losses worldwide annually, mainly for goat producers. Despite its importance, CLA is still poorly characterized. However, with advances in the genomic field, many C. pseudotuberculosis genes have already been characterized, mainly those related to virulence such as phospholipase D. Here, we examined the use of the several available genes of C. pseudotuberculosis and reviewed their applications in vaccine construction, more efficient diagnostics for CLA, and control of this disease, among other applications.

Facteurs de risque et caractéristiques cliniques et lésionnelles de la lymphadénite caséeuse ou maladie des abcès chez les ovins au Maroc

“…Aussi, le pourcentage d'animaux porteurs d'abcès de grande taille augmente avec l'âge (Moller et al, 2000). La virulence de la maladie est liée à l'expression de la phospholipase D par C. pseudotuberculosis (Pépin, 2003 ;D'afonseca et al, 2008 ;Windsor, 2011). L'importance de la maladie tient aux pertes économiques qu'elle engendre.…”

Draft Genome Sequence of Corynebacterium pseudotuberculosis Strain PA07 Biovar ovis , Isolated from a Sheep Udder in Amazonia

“…Thus, the molecular study of the genome of this pathogen and the search for new target genes is an important step for vaccine development (6, 7). …”

Evaluation of the aroA mutant of Corynebacterium pseudotuberculosis in cellular and murine models

“…However, the phospholipase D action must also be considered in this context because it is the main virulence factor causing injury and damage to cell membranes. Activating this gene is undesirable because the virulence of the resulting mutants was abolished and did not stimulate the immune system 24 .…”