INTRODUCTION: A stula-in-ano, is a chronic abnormal communication, usually lined by granulation
tissue, which runs outwards from the anorectal lumen. The standards of anal stula surgery are to
obliterate the stula, prevent recurrence and maintain sphincter work. Ligation of Intersphincteric Fistula Tract (LIFT) is the
most promising surgical technique based on secure closure of the internal opening and removal of the infected crypto
glandular tissue through intersphincteric approach. AIMS: To compare the effectiveness of LIFT over SETON procedure based
on Postoperative pain on day 1 and2, Short term recurrence, Healing, Procedural visits PATIENTS AND METHODS: A
prospective, single centered, interventional study in 60 patients with stula-in-ano admitted to general surgical wards in
Narayana Medical College and Hospital, Nellore. From November 2018 to November 2020. Patients were divided into two
groups, group A including patients undergoing LIFT procedure and group B, including patients undergoing SETON placement
of Fistula-in- ano. RESULTS: Maximum patients were in 41-60 years in the LIFT Group 18(60%), 51-60 years in the SETON group
12(40%). Maximum patients were male 21 in each group (70%), and female were 9 in each group (30%). In the present study,
Visual Analog Scale (0,1,2,3) in LIFT group on POD 1, were 2, 20, 6, 2 and in SETON group on POD 1 were 0, 9, 16, 5 respectively.
Similarly, visual analogue scale (0,1,2,3) in LIFT group on POD 2, were 19.8.3.0 and in SETON group on POD 2 were 5, 20, 5,
0respectively. Patients who underwent LIFT procedure had a satisfactory postoperative period and the wound healed in all the
cases. CONCLUSION: we conclude that LIFT gives good outcomes in terms of Postoperative pain on day 1 and 2, wound
healing rate, single time procedure and recurrence during our short follow-up period of 6 months.