A Deterministic Model of Human Motion Based on Algebraic Techniques and a Sensor Network to Simulate Shoulder Kinematics

Kendricks, Kimberly D.; Taylor, Anthony; Barki, Anum; Tuttle, Ronald F.; Kohles, Sean S.

doi:10.12970/2311-1755.2015.03.01.1

Cited by 13 publications

(2 citation statements)

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“…As recently reviewed [54], the QS mechanism provides huge possibilities for synthetic biology. As a contribution to that field, our regulatory design shows how cell communication can be used to build a robust, yet tunable, phenotypic memory at the level of a bacterial population.…”

Section: Discussionmentioning

confidence: 99%

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The cellular Ising model: a framework for phase transitions in multicellular environments

Weber

Buceta

2016

J. R. Soc. Interface.

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Inspired by the Ising model, we introduce a gene regulatory network that induces a phase transition that coordinates robustly the behaviour of cell ensembles. The building blocks of the design are the so-called toggle switch interfaced with two quorum sensing modules, Las and Lux. We show that as a function of the transport rate of signalling molecules across the cell membrane the population undergoes a spontaneous symmetry breaking from cells individually switching their phenotypes to a global collective phenotypic organization. By characterizing the critical behaviour, we reveal some properties, such as phenotypic memory and hypersensitivity, with relevance in the field of synthetic biology. We argue that our results can be extrapolated to other multicellular systems and be a generic framework for collective decision-making processes.

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Section: Discussionmentioning

confidence: 99%

“…an AND gate, to minimize cross-reactivity. Moreover, there are QS pathways that rely on different signals and show orthogonal signalling, such as that in Staphylococcus aureus [54,55]. Altogether, other alternatives to our design are possible.…”

Section: Discussionmentioning

confidence: 99%