A di-self-crosslinking hyaluronan-based hydrogel combined with type I collagen to construct a biomimetic injectable cartilage-filling scaffold

Ya, Yao; Wang, Peilei; Li, Xing; Xu, Yang; Lu, Gonggong; Jiang, Qing; Sun, Yong; Fan, Yujiang; Zhang, Xingdong

doi:10.1016/j.actbio.2020.05.007

Cited by 53 publications

(32 citation statements)

References 36 publications

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“…Thiol + (metha)/acrylate [72][73][74][75][76][77]84] Amidation [72,74,[77][78][79]81,85]; ether formation [80] Injectable [77,78,81,84]; tissue engineering [72,73,77,84]: cartilage [79,81]; cell encapsulation [84]; wound healing [72]; hemostasis [85] Thiol + Melaimide [78,79] Thiol + Vinyl-sulfone [80,81] Thiol + Catechol [85] Thiol-yne coupling Thiol/yne [83] Amidation [83] Injectable [83]; cell encapsulation [83]; tissue engineering: cartilage [83] Cycloaddition reaction…”

Section: Michael Additionmentioning

confidence: 99%

“…Then, after mixing the modified HA fractions, a rapid Michael addition between both groups occurred by adjusting the pH to physiological conditions. After the initial gelification, a disulfide formation between the thiol groups happened [ 78 , 79 ]. Michael addition may also proceed under physiological conditions between a vinyl sulfone and a thiol group.…”

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

“…Thiol chemistry-mediated hyaluronic acid hydrogels are biocompatible [ 62 , 63 , 72 , 77 , 79 , 83 , 84 , 85 ] and show self-healing and bio-adhesive properties [ 85 ]. They have been employed as injectable materials [ 77 , 78 , 83 , 84 ] which facilitate the application in the human body for tissue engineering purposes These types of hyaluronic acid hydrogels are able to encapsulate cells such as L-929 murine fibroblasts that remained viable and proliferated in vitro [ 62 ]. S. Bian et al encapsulated chondrocytes and L929 cells in hydrogels that were able to proliferate and aggregate forming an extracellular matrix (ECM) [ 63 ].…”

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

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Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

et al. 2021

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Hyaluronic acid (HA) hydrogels display a wide variety of biomedical applications ranging from tissue engineering to drug vehiculization and controlled release. To date, most of the commercially available hyaluronic acid hydrogel formulations are produced under conditions that are not compatible with physiological ones. This review compiles the currently used approaches for the development of hyaluronic acid hydrogels under physiological/mild conditions. These methods include dynamic covalent processes such as boronic ester and Schiff-base formation and click chemistry mediated reactions such as thiol chemistry processes, azide-alkyne, or Diels Alder cycloaddition. Thermoreversible gelation of HA hydrogels at physiological temperature is also discussed. Finally, the most outstanding biomedical applications are indicated for each of the HA hydrogel generation approaches.

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Section: Michael Additionmentioning

confidence: 99%

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

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Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

et al. 2021

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“…In addition, the collagen type I (Col I) was incorporated in dual crosslinking hydrogels because of its capability of inducing MSCs to secrete collagen type II, which can promote cartilage regeneration. [ 165 ]…”

Section: Biomedical Applications Of Injectable Dual Crosslinking Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu

Nie

et al. 2021

Macromolecular Bioscience

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Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.

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“…[ 30 ] also reported that a high concentration of HA in an elastin-like protein–HA hydrogel led to increased marker gene expression and sulfated GAG deposition. However, these HA-based scaffolds showed poor affinity to MSCs or chondrocytes because their negative charges prevented cell adhesion [ 31 ], thus limiting HA–cell interactions.…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired extracellular matrix-mimicking hydrogel scaffold with high cell affinity and immunomodulation ability for growth factor-free cartilage regeneration

Gan

Jiang

et al. 2022

Journal of Orthopaedic Translation

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A di-self-crosslinking hyaluronan-based hydrogel combined with type I collagen to construct a biomimetic injectable cartilage-filling scaffold

Cited by 53 publications

References 36 publications

Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Mussel-inspired extracellular matrix-mimicking hydrogel scaffold with high cell affinity and immunomodulation ability for growth factor-free cartilage regeneration

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