A Diagnostic Model to Improve the Predictability of Natural Pregnancy Potential in Patients with Oligoasthenospermia

Zhang, Tiancheng; Wang, Xin; Wang, Zhikai; Xu, Zhiming; Chen, Liang; Miao, Maohua; Wu, Bin; Wang, Xuemei; Shen, Xiaorong; Wu, Jun; Wang, Ke; Shi, Huijuan; Zheng, Jing

doi:10.12659/msm.922316

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…RXFP1 is a receptor for relaxin and is highly expressed in the testis and vas deferens (Ivell et al, 2011). A study by Zhang et al reported that the lncRNA NKILA regulates osteogenic differentiation through the RXFP1/AKT pathway and also supports a new finding that the RXFP1 is the upstream molecule of AKT (Zhang, Fu, et al, 2020;Zhang, Wang, et al, 2020;Zhang, Cao, et al, 2020).…”

Section: Discussionmentioning

confidence: 87%

“…Among them, AKT1 is identified as the core gene of RJD in the treatment of oligoasthenospermia. Since the PI3K/AKT pathway has been shown to be involved in the apoptosis of testicular cells (Wang et al., 2017), RXFP1, a key factor in the relaxin signalling pathway, is the upstream regulator of AKT (Zhang, Fu, et al., 2020; Zhang, Wang, et al., 2020; Zhang, Cao, et al., 2020). For this reason, we speculated that RJD may play a therapeutic role by regulating the RXFP1/AKT pathway to inhibit testicular cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

“…

Male infertility is not only a troublesome medical bottleneck but also a serious social problem, which brings hidden danger to the harmony and stability of the family. Oligoasthenospermia is the most common cause of male infertility in the clinic (Zhang, Fu, et al, 2020;Zhang, Wang, et al, 2020;Zhang, Cao, et al, 2020). The diagnosis of oligoasthenospermia is mainly related to sperm concentration, sperm density, morphology and the percentage of sperm forward motility (PR%), etc (Colpi et al, 2018).

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confidence: 99%

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Runjing Decoction alleviated cyclophosphamide‐induced oligoasthenospermia rats by inhibiting cell apoptosis via RXFP1/AKT/FOXO1 pathway

Dong

Xia²,

et al. 2021

Andrologia

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Runjing Decoction (RJD) is a prescription of traditional Chinese medicine for the treatment of oligoasthenospermia. However, the molecular mechanism of RJD on oligoasthenospermia still remains unknown. A model of oligoasthenospermia was induced in 30 Sprague Dawley rats by intraperitoneal injection of cyclophosphamide at 35 mg/kg per day for 5 days and treated by intragastric RJD (13.5 g/kg) or L‐carnitine (100 mg/kg) for 14 days. The body weight, testis and epididymis weight, grade A spermatozoa, grade B spermatozoa, the percentage of sperm forward motility (PR%), the sperm activity rate and the sperm density of rats were evaluated before and after RJD treatment. The testis apoptosis was determined by TUNEL staining. The expressions of RXFP1, FoxO1, PI3K, Akt, Bax and Bcl‐2 were determined by qRT‐PCR and Western blot, respectively. After RJD treatment, the grade A spermatozoa, sperm PR%, sperm activity and sperm density were significantly increased relative to those in model rats. Cell apoptosis of testis tissue was reversed by RJD. RJD suppressed cell apoptosis, inhibited the expression of RXFP1, FOXO1, PI3K, AKT and Bax, and promoted the expression levels of Bcl‐2 in testicular tissue of oligoasthenospermia rats. RJD could alleviate sperm quality and testis damage in oligoasthenospermia rats by inhibiting RXFP1/AKT/FOXO1 pathway.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Runjing Decoction alleviated cyclophosphamide‐induced oligoasthenospermia rats by inhibiting cell apoptosis via RXFP1/AKT/FOXO1 pathway

Dong

Xia²,

et al. 2021

Andrologia

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“…Among these, male factors may be the primary cause of infertility in approximately 50% of couples. In addition, infertility can cause serious psychological stress and social problems, which brings considerable economic burden to patients and the health care system [3,4] . Thus, it is necessary to facilitate early diagnoses and propose appropriate treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Eleven Mutations in Six Genes Causing Abnormal Sperm Morphology: A Case Series

Zhong¹,

Liu²,

Wang³

et al. 2021

Preprint

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Objective: Infertility has become a major health problem worldwide, approximately 10%–15% of male infertility cases can be attributed to genetic mutations. However, the genetic factors contributing to male infertility remain largely unknown. This study aimed to identify genetic mutations associated with morphological abnormalities in sperm.Methods: In this study, we assessed the semen parameters of 60 patients with sperm morphological abnormalities by semen analysis, and subsequently performed targeted next-generation sequencing (NGS) to identify gene mutations. Results: Of the 60 cases of male infertility, 8 individuals (13%) were identified as carrying genetic mutations. In brief, patient 1 carried two heterozygous mutations of SUN5, including c.1066C>T and c.638delC; Patient 2 and Patient 3 had a 109.73 kb homozygous deletion on chromosome 12 in DPY19L2; patient 4 presented two heterozygous mutations (c.1670_1671delinsTT and c.255_258del) of DPY19L2; patient 5 carried a homozygous variant c.1159+1G>A of CCDC40; patient 6 had a heterozygous mutation c.38_43del in the SEPT12 gene; patient 7 had two heterozygous mutations in DNAH1 (c.10060_10061insATCT and c.12278T>C), and patient 8 presented two heterozygous mutations of CFAP43 (c.3658C>T and c.823del). Conclusions: We identified gene mutations associated with sperm morphological abnormalities in a series of male infertility cases. Eight of sixty individuals were identified as carrying gene mutations. Genetic mutations of SUN5, DPY19L2, CCDC40, SEPT12, DNAH1, and CFAP43 might be responsible for male infertility. Our study expanded the landscape of gene mutations related to sperm morphological abnormalities, which might provide new insights into the genetics underlying male infertility.

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“…A survey by the World Health Organization shows that infertility is estimated to affect 10%–15% of couples, and approximately 50% of these couples are infertile because of male infertility 1 . Infertility might become the third disease affecting human health and life quality, behind tumors and cardiovascular disease 2 .…”

Section: Introductionmentioning

confidence: 99%

Establishment of an oligoasthenospermia mouse model based on TAp73 gene suppression

Liu

Deng

Zhu

et al. 2021

Anim Models and Exp Med

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A survey by the World Health Organization shows that infertility is estimated to affect 10%-15% of couples, and approximately 50% of these couples are infertile because of male infertility. 1 Infertility might become the third disease affecting human health and life quality, behind tumors and cardiovascular disease. 2 With a gradual increase in incidence, male infertility has received increasing attention worldwide. 3 Oligoasthenospermia has become a major etiology of

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A Diagnostic Model to Improve the Predictability of Natural Pregnancy Potential in Patients with Oligoasthenospermia

Cited by 3 publications

References 8 publications

Runjing Decoction alleviated cyclophosphamide‐induced oligoasthenospermia rats by inhibiting cell apoptosis via RXFP1/AKT/FOXO1 pathway

Runjing Decoction alleviated cyclophosphamide‐induced oligoasthenospermia rats by inhibiting cell apoptosis via RXFP1/AKT/FOXO1 pathway

Eleven Mutations in Six Genes Causing Abnormal Sperm Morphology: A Case Series

Establishment of an oligoasthenospermia mouse model based on TAp73 gene suppression

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