In this decade, manufacturing companies are facing events that disrupt delicate balances and experiencing tangible challenges that cannot be deferred. Among these, the acceleration of technological transformation to follow the introduction of Industry 4.0, the difficulty in sourcing raw materials and accessing different markets due first to the COVID 19 pandemic and more recently to geopolitical tensions and conflicts. In this scenario, traditional supply chain models need to transform into digital supply chains (DSCs), where functional silos are broken down to enable end-toend visibility, agility, collaboration, and resilience to such shocks. The literature on the subject is still immature and many concepts are still vague and undefined. In this regard, this article aims to answer the following questions: (i) What are the main research areas within the topic? (ii) What is the development trajectory of the topic? (iii) What are the main digital technologies that can support DSC capabilities? (iv) What can be its research agenda? For this purpose, this paper aims at reviewing the existing scientific production on DSCs, combining a systematic review with bibliometric tools. The resulting framework can serve as a preliminary guide for companies facing the challenges listed above and can open up future research that can validate the results empirically.