A Dimeric Magnesium(I) Compound as a Facile Two‐Center/Two‐Electron Reductant

Bonyhady, Simon J.; Green, Shaun P.; Jones, Cameron; Nembenna, Sharanappa; Stasch, Andreas

doi:10.1002/anie.200900331

Cited by 128 publications

(66 citation statements)

References 24 publications

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“…The N-hetero gallacyclopropane then rapidly dimerizes to give the 1,4-digalla-2,5-diazacyclohexane derivative 6,w hich is 40.1 kcal mol À1 lower in energy than the galla-azacyclopropane. [32] Transition metal carbene and silylene complexes form cycloadducts with isocyanates. [10c] This type of oxidative addition reaction of unsaturated hydrocarbons is commonf or derivatives of heavierl ow-valentG roup 13 elements.…”

Section: Resultsmentioning

confidence: 99%

Gallium “Shears” for C=N and C=O Bonds of Isocyanates

Dodonov

Chen

Zhao

et al. 2019

Chemistry A European J

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Digallane [L 1 GaÀGaL 1 ]( 1,L 1 = dpp-bian = 1,2-[(2,6-iPr 2 C 6 H 3 )NC] 2 C 12 H 6 )r eacts with RN=C=O( R = Ph or To s) by [2+ +4] cycloaddition of the isocyanate C=Nb onds across both of its C=CÀNÀGa fragments to afford [L 1 (O=CÀNR)GaÀ Ga(RNÀC=O)L 1 ]( R = Ph, 3;R = Tos, 4). The reactions with both isocyanates result in new CÀCa nd NÀGa single bonds.In the case of allyl isocyanate, the [2+ +4] cycloaddition across one C=CÀNÀGa fragment of 1 is accompanied by insertion of as econd allyl isocyanate molecule into the GaÀNb ond of the same fragment to afford compound [L 1 GaÀGa(AllNÀ C=O) 2 L 1 ]( 5)( All = allyl). In the presence of Na metal, the related digallane [L 2 GaÀGaL 2 ]( 2;L 2 = dpp-dad = [(2,6-iPr 2 C 6 H 3 )NC(CH 3 )] 2 )i sc onverted into the gallium(

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Section: Resultsmentioning

confidence: 99%

Gallium “Shears” for C=N and C=O Bonds of Isocyanates

Dodonov

Chen

Zhao

et al. 2019

Chemistry A European J

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“…Statistical analysis was performed in accordance with the Cochrane Handbook for Statistical Review of Interventions. 27,28 The DerSimonian and Laird random effect 29 was chosen, because variation between studies' populations and high heterogeneity in BP analysis was observed. A P value <0.05 was considered statistically significant.…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

Effect of Probiotics on Blood Pressure

et al. 2014

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Abstract-Previous human clinical trials have shown that probiotic consumption may improve blood pressure (BP) control.The aim of the present systematic review was to clarify the effects of probiotics on BP using a meta-analysis of randomized, controlled trials. PubMed, Scopus, Cochrane Library (Central), Physiotherapy Evidence Database, and Clinicaltrial.gov databases were searched until January 2014 to identify eligible articles. Meta-analysis using a random-effects model was chosen to analyze the impact of combined trials. Nine trials were included. Probiotic consumption significantly changed systolic BP by −3.56 mm Hg (95% confidence interval, −6.46 to −0.66) and diastolic BP by −2.38 mm Hg (95% confidence interval, −2.38 to −0.93) compared with control groups. A greater reduction was found with multiple as compared with single species of probiotics, for both systolic and diastolic BP. Subgroup analysis of trials with baseline BP ≥130/85 mm Hg compared with <130/85 mm Hg found a more significant improvement in diastolic BP. Duration of intervention <8 weeks did not result in a significant reduction in systolic or diastolic BP. Furthermore, subgroup analysis of trials with daily dose of probiotics <10 11 colony-forming units did not result in a significant meta-analysis effect. The present meta-analysis suggests that consuming probiotics may improve BP by a modest degree, with a potentially greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks, or daily consumption dose is ≥10 The online-only Data Supplement is available with this article at http://hyper.ahajournals.org/lookup/suppl

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“…Remarkably,s tarting from this ligand platformi tw as also possible to access dimeric low-oxidation-state magnesium(I) complexes,w hich turned out to be versatile two-center two-electron reducinga gents. [16][17][18][19][20][21][22][23] This rising interest also initiated research into other promising ligand platforms that mimic the chelating ability of the ubiquitous NacNacl igand, in particular the feature that two imine nitrogena toms functiona sL ewis donors to ac oordinating metal ion to form as ix-membered metallaheterocycle.E xamples are the bis(2-pyridyl)methane ligand system and its N, P, and As bridged derivatives with benzo-fused imine moieties (Scheme 2, left). [24][25][26][27][28][29][30][31][32][33] Furthermore, an ew ligand class arose when the 2-pyridyl residues were exchanged forb enzannulated oxazoline sidearms.…”

Section: Introductionmentioning

confidence: 99%

A Novel Bulky Heteroaromatic‐Substituted Methanide Mimicking NacNac: Bis(4,6‐tert‐butylbenzoxazol‐2‐yl)methanide in s‐Block Metal Coordination

Koehne

Bachmann

Niklas

et al. 2017

Chemistry A European J

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A novel bulky bis(4,6-tBu-benzoxazol-2-yl)methane ligand was synthesized in a straightforward three-step synthesis. The corresponding complexes [Li{(4,6-tBu-NCOC H ) CH}THF], [K{η -(4,6-tBu-NCOC H ) CH}] , and [MgCl{(4,6-tBu-NCOC H ) CH}(THF) ] were obtained upon metalation with alkaline or alkaline-earth-metal reagents. Reduction of [MgCl{(4,6-tBu-NCOC H ) CH}(THF) ] with potassium metal or KC led to the formation of the homoleptic compound [Mg{(4,6-tBu-NCOC H ) CH} ]. All compounds were fully characterized. Their solid-state structures as well as their behavior in solution, which was analyzed with the help of advanced NMR spectroscopic techniques, are discussed in detail.

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A Dimeric Magnesium(I) Compound as a Facile Two‐Center/Two‐Electron Reductant

Cited by 128 publications

References 24 publications

Gallium “Shears” for C=N and C=O Bonds of Isocyanates

Gallium “Shears” for C=N and C=O Bonds of Isocyanates

Effect of Probiotics on Blood Pressure

A Novel Bulky Heteroaromatic‐Substituted Methanide Mimicking NacNac: Bis(4,6‐tert‐butylbenzoxazol‐2‐yl)methanide in s‐Block Metal Coordination

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