A direct comparison of experimental methods to measure dimensions of synthetic nanoparticles

Eaton, Peter; Quaresma, Pedro; Soares, Cristina; Neves, Cristina S.; Almeida, Miguel Peixoto de; Pereira, Eulália; West, Paul

doi:10.1016/j.ultramic.2017.07.001

Cited by 261 publications

(167 citation statements)

References 17 publications

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“…This can be explained on the basis that DLS measures the particles hydrodynamic diameter, which includes polymer shells and hydration layer leading to a larger particle size. 67,68 In addition, DLS is extremely sensitive to the dispersion/aggregation behavior of the particles in solution. 68 Selective accumulation and targeting of naringin in inflamed tissues and tumor cells can still be proposed.…”

Section: Mohamed Et Almentioning

confidence: 99%

“…67,68 In addition, DLS is extremely sensitive to the dispersion/aggregation behavior of the particles in solution. 68 Selective accumulation and targeting of naringin in inflamed tissues and tumor cells can still be proposed. Consequently, an enhancement of antiulcer and antitumor activities of naringin can be expected upon micellization with PF68.…”

Section: Mohamed Et Almentioning

confidence: 99%

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Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Mohamed¹,

Hashim²,

Yusif³

et al. 2018

IJN

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Naringin is one of the most interesting phytopharmaceuticals that has been widely investigated for various biological actions. Yet, its low water solubility, limited permeability, and suboptimal bioavailability limited its use. Therefore, in this study, polymeric micelles of naringin based on pluronic F68 (PF68) were developed, fully characterized, and optimized. The optimized formula was investigated regarding in vitro release, storage stability, and in vitro cytotoxicity vs different cell lines. Also, cytoprotection against ethanol-induced ulcer in rats and antitumor activity against Ehrlich ascites carcinoma in mice were investigated. Nanoscopic and nearly spherical 1:50 micelles with the mean diameter of 74.80±6.56 nm and narrow size distribution were obtained. These micelles showed the highest entrapment efficiency (EE%; 96.14±2.29). The micelles exhibited prolonged release up to 48 vs 10 h for free naringin. The stability of micelles was confirmed by insignificant changes in drug entrapment, particle size, and retention (%) (91.99±3.24). At lower dose than free naringin, effective cytoprotection of 1:50 micelles against ethanol-induced ulcer in rat model has been indicated by significant reduction in mucosal damage, gastric level of malondialdehyde, gastric expression of tumor necrosis factor-alpha, caspase-3, nuclear factor kappa-light-chain-enhancer of activated B cells, and interleukin-6 with the elevation of gastric reduced glutathione and superoxide dismutase when compared with the positive control group. As well, these micelles provoked pronounced antitumor activity assessed by potentiated in vitro cytotoxicity particularly against colorectal carcinoma cells and tumor growth inhibition when compared with free naringin. In conclusion, 1:50 naringin–PF68 micelles can be represented as a potential stable nanodrug delivery system with prolonged release and enhanced antiulcer as well as antitumor activities.

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Section: Mohamed Et Almentioning

confidence: 99%

Section: Mohamed Et Almentioning

confidence: 99%

Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Mohamed¹,

Hashim²,

Yusif³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…This grain size was much bigger than that of evaluated values from SEM images. This enlargement in the grain size may be due to the involution of true particle size with that of the AFM point and also on the preparation of samples for AFM [39].…”

Section: X-ray Diffraction Analysismentioning

confidence: 99%

Optimization Properties and Characterization of Green Synthesis of Copper Oxide Nanoparticles Using Aqueous Extract of Cordia myxa L. Leaves

Thamer¹,

Muftin²,

Al-Rubae³

2018

Asian J. Chem.

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Copper oxide nanoparticles (CuONPs) were green synthesized using aqueous extract of Cordia myxa L. leaves as reducing and capping agent. The synthesized nanoparticles were characterized by UV-visible spectrophotometer, FTIR, X-ray diffraction, scanning electron microscope and atomic force microscope. The prepared copper oxide nanoparticles showed surface plasmon resonance centered at 400 nm. The optimized condition for the synthesis of copper nanoparticles revealed that the aqueous extract of Cordia myxa L. leaves:copper sulfate ratio was 1:3, pH was 9 and copper sulfate concentration was 40 mM. FTIR results showed that stabilization and formation of CuONPs were due to phenolic groups and amines in plant extract. The XRD pattern showed that the particles are monoclinic in nature. The crystalline morphology and size of the nanoparticles were determined by scanning electron microscope. Presence of elemental copper was revealed by EDX analysis. Size range was from 20 to 106.81 nm was determined by atomic force microscope.

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“…It is known that SEM and TEM images could be used to characterize nanoparticles (Noël et a l ., ). But, Eaton et al () noted that SEM is a more useful tool for especially detection of the larger than 50 nm nanoparticles diameter. Sreekumar, Goycoolea, Moerschbacher, and Rivera‐Rodriguez () reported that the diameter of chitosan nanoparticles could be found between 200 and 2,500 nm.…”

Section: Resultsmentioning

confidence: 99%

Use of characterized chitosan nanoparticles integrated in poly(vinyl alcohol) nanofibers as an alternative nanoscale material for fish balls

Ceylan

2018

Journal of Food Safety

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Chitosan nanoparticle integrated in poly(vinyl alcohol) nanofiber (IPN) was obtained by using the electrospinning technique. Optimization parameters of the electrospinning process were defined to be 22 kV, 0.6 mL/hr, and 9 cm, respectively. Zeta potential (ZP: 15.06 mV), zeta size (ZS: 397.93 nm), and morphological properties (scanning electron microscopy: <600 nm) of the obtained nanoscale samples were determined. The overall sensory quality of IPN samples was protected better until fifth day of the cold storage. Also, the use of nanoscale material delayed the rapid increase in the total volatile basic nitrogen (TVBN; p < .05) and in the pH values. Microbial growth (total psychrophilic bacteria count, TPBc) in the IPN samples was found to be 3.98, 4.34, and 5.68 log cfu/g. However, microbial spoilage was determined to be more rapidly in the control group samples during 5‐days cold storage period (p < .05). The use of 0.02‐g of nanomaterial limited the total psychrophilic bacteria (TPB) growth in fish balls (up to 13%). The results suggested that IPN application would be a promising approach to keep the fish quality. In this sense, the used nanotechnology application in this study can guide other food nanotechnology applications. Practical applications The use of IPNs delayed the deterioration in fish balls. In the early stages of the storage period, the nanoscale application was more successful to delay the microbiological growth and chemical deterioration. TPBc, TVBN, and especially overall sensory score analysis results revealed the differences between the control group samples and IPN samples. The combination use of nanoparticle and nanofiber in a nanoscale structure could be evaluated as a brilliant application for the further studies in food preservation.

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A direct comparison of experimental methods to measure dimensions of synthetic nanoparticles

Cited by 261 publications

References 17 publications

Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Optimization Properties and Characterization of Green Synthesis of Copper Oxide Nanoparticles Using Aqueous Extract of Cordia myxa L. Leaves

Use of characterized chitosan nanoparticles integrated in poly(vinyl alcohol) nanofibers as an alternative nanoscale material for fish balls

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