A Disease Must Be Considered in the Differential Diagnosis of Ascites: Familial Mediterranean Fever

Bektaş, Mehmet; Altan, Mehmet; Kutlay, Sim; Gören, Deniz; Soykan, İrfan; Korkut, Esin; Çetinkaya, Hülya; Özden, Ali

doi:10.1159/000116724

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…A response to colchicine may be either complete or partial. After colchicine treatment, ascites completely disappears in some patients and decreases in others (8,20,21). Cakir et al (10) reported a six-year-old child who presented with refractory ascites and was diagnosed with FMF.…”

Section: Discussionmentioning

confidence: 99%

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A rare cause of massive ascites: Familial Mediterranean fever

Aslan

Demir²,

Esen³

et al. 2012

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

“…Chronic ascites resulting from FMF is an uncommon complication. To the best of the authors' knowledge, there have been few reports in the literature to date about massive chronic ascites in this genetic disease (7)(8)(9)(10).…”

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confidence: 99%

A rare cause of massive ascites: Familial Mediterranean fever

Aslan

Demir²,

Esen³

et al. 2012

Turk J Gastroenterol

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“…Adult-onset FMF and TRAPS patients may develop atypical manifestations, including recurrent serosal involvement as the only clinical feature [18,24,25] . In addition, cases of FMF presenting only with ascites (even massive) as the first sign of disease have been reported [26,27] . As already commented about all the aforementioned disorders, our case did not fulfill either TRAPS diagnostic criteria [17] .…”

Section: Consanguinity Of Parentsmentioning

confidence: 99%

Idiopathic chronic polyserositis with massive ascites responding to colchicine in an adult: A case report

Fernández-Ayala

Carrascosa

Salcines-Caviedes

2014

CRIM

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Objective: While there are many different causes of ascites, most cases are due to cirrhosis. However, a serum/ascites albumin gradient <1.1 indicates that the ascites is not induced by portal hypertension and mandates a search for other etiologies, including causes of serositis. We describe a 70-year-old patient with persistent ascites and pleuropericarditis who underwent a successful outcome while on colchicine treatment. Methods:This study was delineated on a case-report basis. Besides supportive care measures, we performed a comprehensive clinical and complementary assessment of the patient, which included laboratory tests, imaging techniques, endoscopic evaluation, full microbiological and pathological studies, diagnostic laparoscopy and thoracoscopy, and genetic testing for autoinflammatory diseases. Results:Diagnostic workup failed to demonstrate the presence of an underlying etiologic disorder. Large-volume paracentesis was performed once monthly during 13 consecutive months due to painless, massive accumulation of peritoneal fluid. Eventually, colchicine therapy induced a dramatic response with clinical and radiological disappearance of polyserositis within three months of starting on the drug. While on colchicine, the disease has not recurred throughout a thirty two months period of follow-up so far. To our knowledge, the occurrence of idiopathic, chronic refractory ascites and pleuropericarditis resolved under colchicine treatment in an adult not diagnosed with Familial Mediterranean Fever is an exceptional event.Conclusion: We suggest that in adult patients suffering from idiopathic chronic polyserositis including massive ascites the possible existence of an underlying autoinflammatory condition should be sought. In such a case, a colchicine trial might be regarded as an early suitable therapeutic option.

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Familial Mediterranean fever with chronic ascites: a case report and a review of literature

et al. 2009

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Familial Mediterranean fever (FMF) is an autosomal recessive inflammatory disease especially seen in Turks, Sephardic Jews, Armenians, and Arabs. Peritoneal and pleural inflammation, arthritis, erysipelas-like erythema, and arthralgia are well-known features of FMF. A small amount of peritoneal fluid collection can be seen during peritoneal attacks in FMF patients, but chronic ascites is a rather rare complication. We herein report a female FMF patient who developed chronic ascites. She was compound heterozygote for M694V/M680I mutation of the MEFV gene. Aspiration of the ascites fluid revealed a small amount of erythrocytes and mesothelial cells. After dose adjustment of colchicine the amount of ascites decreased. In conclusion, FMF should be considered in the differential diagnosis of chronic ascites in populations where the disease is endemic.

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A Disease Must Be Considered in the Differential Diagnosis of Ascites: Familial Mediterranean Fever

Cited by 3 publications

References 6 publications

A rare cause of massive ascites: Familial Mediterranean fever

A rare cause of massive ascites: Familial Mediterranean fever

Idiopathic chronic polyserositis with massive ascites responding to colchicine in an adult: A case report

Familial Mediterranean fever with chronic ascites: a case report and a review of literature

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