A disposable edoxaban sensor chip using carbon paste electrode grafted with molecularly imprinted polymer

Yoshimi, Yasuo; Kani, Shohei; Aaryashree, Aaryashree

doi:10.1007/s10047-023-01392-1

Cited by 4 publications

(1 citation statement)

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“…Moreover, this sensor was also evaluated using a pharmaceutical formulation and edoxaban-spiked human plasma samples. Similarly, a sensor chip based on a carbon paste electrode embedded with molecularly imprinted polymers and p-styrene sulfonate was developed to detect and quantify edoxaban [102]. The interaction of edoxaban through the cavities created inside the grafted layer enhances the oxidation current of ferrocene, which is used as the redox probe.…”

Section: Electrochemical Sensors For Anticoagulants Using Modified El...mentioning

confidence: 99%

Electrochemical Monitoring in Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Molecules

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The process of blood coagulation, wherein circulating blood transforms into a clot in response to an internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting neither occurs too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their targets within the coagulation enzyme system, and emphasises the electrochemical methods employed in anticoagulant testing. Electrochemical sensors for anticoagulant monitoring are categorised into two types. The first type focuses on assays measuring thrombin activity via electrochemical techniques. The second type involves modified electrode surfaces that either directly measure the redox behaviours of anticoagulants or monitor the responses of standard redox probes in the presence of these drugs. This review comprehensively lists different electrode compositions and their detection and quantification limits. Additionally, it discusses the potential of employing a universal calibration plot to replace individual drug-specific calibrations. The presented insights are anticipated to significantly contribute to the sensor community’s efforts in this field.

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Section: Electrochemical Sensors For Anticoagulants Using Modified El...mentioning

confidence: 99%