A DNA functionalized metal–organic framework combined with magnesium peroxide nanoparticles: targeted and enhanced photodynamic therapy

Sun, Xinran; Zhang, Guoda; Ding, Xilai; Liu, Ying-Yan; Chen, Kaixiu; Shi, Pengfei; Zhang, Shusheng

doi:10.1039/d1qm01475g

Cited by 13 publications

(10 citation statements)

References 46 publications

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“…Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxide with water has a dual role of inducing oxidative stress and producing surplus oxygen from the reaction with molecules such as catalyse enzymes. Tese alleviate tumor hypoxia thereby reversing the low oxygen levels observed in the tumor microenvironment [29,216,217]. In addition, the properties of metal peroxides may be precisely paired with other molecules such as photosensitizers, enzymes, metal nanoparticles, Fenton reagents, or chemotherapeutic medications, to achieve combination therapies including photodynamic therapy, chemodynamic therapy, and chemotherapy [170,[185][186][187].…”

Section: Discussionmentioning

confidence: 99%

“…Metal peroxides have attracted particular research interest in biology and medicine due to their peculiar chemical reactions, associated reaction products, and particular biochemical efects of the released metal ions [28,29]. Recently, versatile metal peroxide nanoparticles including CuO 2 , CaO 2 , MgO 2 , ZnO 2 , BaO 2 , and TiOx have been developed for therapeutic applications [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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“…Furthermore, this group also synthesized Hf‐MOF‐MgO 2 by modifying MgO 2 with Hf‐MOF, which was isomorphic to PCN‐224 ( Figure a). [ 107 ] Then, the deoxyribonucleic acid (DNA) of breast cancer cells was modified on Hf‐MOF‐MgO 2 to form Hf‐MOF‐MgO 2 /DNA. 4T1 DNA could specifically target 4T1 cells to achieve targeted therapy, and MgO 2 could react with H 2 O to produce O 2 to solve the problem of tumor hypoxia.…”

Section: Increasing O2 Concentration In Tumorsmentioning

confidence: 99%

Section: Increasing O2 Concentration In Tumorsmentioning

confidence: 99%

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Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Zhang

Jin

et al. 2023

Adv Healthcare Materials

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Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and low toxicity side effects, has been widely used in the clinical therapy of various tumors, especially superficial tumors. However, the tumor microenvironment (TME) presents hypoxia due to the low oxygen (O2) supply caused by abnormal vascularization in neoplastic tissues and high O2 consumption induced by the rapid proliferation of tumor cells. The efficacy of oxygen‐consumping PDT can be hampered by a hypoxic TME. To address this problem, researchers have been developing advanced nanoplatforms and strategies to enhance the therapeutic effect of PDT in tumor treatment. This review summarizes recent advanced PDT therapeutic strategies to against the hypoxic TME, thus enhancing PDT efficacy, including increasing O2 content in TME through delivering O2 to the tumors and in situ generations of O2; decreasing the O2 consumption during PDT by design of type I photosensitizers. Moreover, recent synergistically combined therapy of PDT and other therapeutic methods such as chemotherapy, photothermal therapy, immunotherapy, and gas therapy is accounted for by addressing the challenging problems of mono PDT in hypoxic environments, including tumor resistance, proliferation, and metastasis. Finally, perspectives of the opportunities and challenges of PDT in future clinical research and translations are provided.

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A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

Sun,

Yuan,

Zhang

et al. 2024

Tungsten

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A DNA functionalized metal–organic framework combined with magnesium peroxide nanoparticles: targeted and enhanced photodynamic therapy

Abstract: Photodynamic therapy (PDT) has become a promising therapeutic approach in clinical. How to improve the efficiency of PDT is still a research hotspot due to tumor hypoxia and insufficient aggregation...

Cited by 13 publications

References 46 publications

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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