A DNA‐intercalating complex of a pyrene derivative with the ¹⁸⁸Re(CO)₃‐moiety as a potentially improved radiotherapeutic drug

Abstract

The effectiveness of radiotherapy with the '"Re nuclide could be improved by inducing damage selectively to the DNA of the cancerous cells, which is more sensitive to radiations than the rest of the cell. A complex of a "'Re(CO)3 core with a pyrene derivative has been synthesized for further investigation of the proof of principle that DNA localized '"Re can cause DNA strandbreaks at.low activity conc entrations.